Laboratory of Polypeptide Drugs and Delivery - Dr Peter Moyle

Want to advance your pharmacy career with a PhD? Applications for the Alan Grant-Taylor Memorial Scholarship are now open, with up to $42,192 p.a. available with the UQ School of Pharmacy for candidates to conduct research in the field of community pharmacy practice. Applications close 26 March 2023. Find out more: https://fal.cn/3vZkt

Want to advance your career? UQ PhD scholarships of up to $38,092 p.a. are available at the UQ School of Pharmacy
for candidates to conduct high quality research in the field of community pharmacy practice.

Applications close 28 September 2020: https://pharmacy.uq.edu.au/alan-grant-taylor-memorial-scholarship

Exciting funded PhD Scholarship opportunity on targeted gene delivery platforms. Find further information at

University of Queensland, School of Pharmacy PhD Projects, Programs & Scholarships Find A PhD. Search Funded PhD Projects, Programs & Scholarships at University of Queensland, School of Pharmacy.

international applications close Jan 17 2020 https://bit.ly/352Gk53. Looking for applicants to work on ARC project. See http://moylelab.com for information and contact details

Scholarships and scholarship rounds The UQ Graduate School manages a number of scholarship schemes that provide financial support for tuition fees, living costs and travel which enables you to focus on your research.

Congratulations to PhD student Zhenghui Xu on the submission of your thesis and the publication of your 1st research article in the prestigious Journal of Controlled Release.

His publication describes a simple, efficient Sortase A enzyme-mediated means to site-specifically conjugate Toll-like receptor 2 agonist lipopeptide adjuvants onto recombinant protein antigens.

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Australian Research Council (ARC) Grant Success:

We thank the Australian Research Council and the Australian Government for awarding our laboratory and collaborators (Prof Toth, UQ) with a 2020 ARC Discovery Project Grant for 3 years.

We look forward to the research and training opportunities that this funding will provide.

Project Summary: Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.

Research Management System - Scheme Round Statistics for Approved Proposals - Discovery Projects 2020 round 1 RMS is the ARC’s Research Management System, a web-based system used by eligible researchers to prepare and submit research proposals and assessments under the ARC National Competitive Grants Program (NCGP).

See our latest review on biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines in Biotechnology Advances

Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines - ScienceDirect Traditional vaccination approaches (e.g. live attenuated or killed microorganisms) are among the most effective means to prevent the spread of infectious diseases. These approaches, nevertheless, have failed to yield successful vaccines against many important pathogens. To overcome this problem, met...

Read about our exciting new breast cancer targeted siRNA/pDNA delivery platform

Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells - ScienceDirect The development of carriers for the delivery of oligonucleotide therapeutics is essential for the successful translation of gene therapies to the clinic. In the present study, a delivery system, which combines the fusogenic lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) with a well-defin...

Congratulations to Zhenghui Xu on the acceptance and publication of his review on bioconjugation approaches to produce self-adjuvanting vaccines in Bioconjugate Chemistry

Bioconjugation Approaches to Producing Subunit Vaccines Composed of Protein or Peptide Antigens and Covalently Attached Toll-Like Receptor Ligands Bioconjugation Approaches to Producing Subunit Vaccines Composed of Protein or Peptide Antigens and Covalently Attached Toll-Like Receptor Ligands

Congratulations to Anjuman Begum for her recently accepted publication comparing the expression of the bombesin receptor on different cell lines to uptake of bombesin peptides.

Link:

Investigation of Bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor Targeted drug delivery provides a means to improve efficacy, while reducing side effect and the dose of drug that needs to be delivered. The bombesin peptide is a potential targeting moiety for various types of cancers. However, the development of targeted delivery systems requires highly characteri...

See our latest article on optimising -L-lysine for http://bit.ly/2a2QNGq

Peptide-Based Multicomponent Oligonucleotide Delivery Systems: Optimisation of Poly-l-lysine Dendrons for Plasmid DNA Delivery - Online First - Springer Gene therapy is a promising means to treat or prevent diseases either through gene silencing or expression. Some of the most effective delivery agents are polycationic dendrimers, which are highly branched constructs incorporating many positively charged groups. Two of the most effective dendrimers…