Absolut Chemistry

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Congratulations to our new #NobelPrize laureate in chemistry Morten Meldal! Meldal found out he had been awarded the prize while at University of Copenhagen, Denmark where his colleagues celebrated upon learning the news. Video Credit: Jiwoong Lee

The Nobel Prize in Chemistry 2022 is about finding new chemical ideals and letting simplicity and functionality take precedence.

The 2022 chemistry laureate Barry Sharpless, who is now being awarded his second Nobel Prize in Chemistry, was the one who started the snowball rolling. Around the turn of the century, he coined the concept of click chemistry for a functional form of chemistry, where molecular building blocks snap together quickly and efficiently. The snowball became an avalanche when 2022 chemistry laureates Morten Meldal and Barry Sharpless – independently of each other – discovered what has become the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition.

Click chemistry’s simplicity has led to the reaction becoming tremendously popular, both at research laboratories and in industrial development. Among other things, click reactions facilitate the production of new materials that are fit for purpose. In pharmaceutical research, click chemistry is used to produce and optimise substances that can potentially become pharmaceuticals. There are many examples of what click chemistry can achieve.

Carolyn Bertozzi – the third of this year’s chemistry laureates – developed click reactions that can be used inside living organisms. Her bioorthogonal reactions – which occur without disturbing the normal chemistry of the cell – are used globally to map how cells function. Some researchers are now investigating how these reactions can be used to diagnose and treat cancer.

We do not yet know whether these new therapies will work – but one thing is clear: research has just touched on the enormous potential of click chemistry and bioorthogonal chemistry.

The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

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BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2022 Nobel Prize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

The 2022 Nobel Prize in Chemistry is about making difficult processes easier. Barry Sharpless and Morten Meldal have laid the foundation for a functional form of chemistry – click chemistry – in which molecular building blocks snap together quickly and efficiently. Carolyn Bertozzi has taken click chemistry to a new dimension and started utilising it in living organisms.

Chemists have long been driven by the desire to build increasingly complicated molecules. In pharmaceutical research, this has often involved artificially recreating natural molecules with medicinal properties. This has led to many admirable molecular constructions, but these are generally time consuming and very expensive to produce.

Barry Sharpless – who is now being awarded his second Nobel Prize in Chemistry – started the ball rolling. Around the year 2000, he coined the concept of click chemistry, which is a form of simple and reliable chemistry, where reactions occur quickly and unwanted by-products are avoided.

Shortly afterwards, Morten Meldal and Barry Sharpless – independently of each other – presented what is now the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition. This is an elegant and efficient chemical reaction that is now in widespread use. Among many other uses, it is utilised in the development of pharmaceuticals, for mapping DNA and creating materials that are more fit for purpose.

Carolyn Bertozzi took click chemistry to a new level. To map important but elusive biomolecules on the surface of cells – glycans – she developed click reactions that work inside living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell.

These reactions are now used globally to explore cells and track biological processes. Using bioorthogonal reactions, researchers have improved the targeting of cancer pharmaceuticals, which are now being tested in clinical trials.

Click chemistry and bioorthogonal reactions have taken chemistry into the era of functionalism. This is bringing the greatest benefit to humankind.

Learn more
Press release: https://bit.ly/3RmwWAF
Popular information: https://bit.ly/3S944gk
Advanced information: https://bit.ly/3xO1x2R

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