Meshul Special

Meshul Special Our lab researches Parkinson's Disease and is lead by Dr. Charles Meshul. Check out our posters: https://goo.gl/ROzDwJ
And papers: https://goo.gl/n9wq13

Our laboratory is mainly involved in investigating electron microscopic/immunocytochemical changes in synapses within the brain following various drug treatment procedures or lesions of the nigrostriatal pathway, as a model for Parkinson’s disease (PD), and correlating these findings with functional/protein changes using in vivo microdialysis/westerns and motor behaviors in mice. Using a new progr

essive mouse model of PD developed in my lab, by administering increased doses of the toxin, MPTP, we have found that exposure of mice to a socially enriched environment can, after the initiation of the loss of dopamine, slow down or block the neurochemical and motor behavioral deficits due to continued treatment with MPTP. We are currently investigating 1.) the therapeutic affects of exercise in this same progressive MPTP model of PD in both young and aged mice, 2.) the effect of MPTP in a double floxed line of mice (lox-P-Vgat; lox-P-Vglut2) in which either the motor cortex is activated or the subthalamic nucleus is inactivated by infusion of AAV-cre. Either treatment results in neuroprotection from dopamine loss in the striatum and substantia nigira, and 3.) the effect of a flavinoid derivative, which specifically activates the brain derived neurotrophic factor receptor, TrkB, on blocking the further loss of dopamine during continued MPTP treatment.

03/09/2020

All of our procedures can be found in the notes section

Our Saturday Academy High school students did a fantastic job - in the lab and at their presentations! Good job ladies!
08/16/2016

Our Saturday Academy High school students did a fantastic job - in the lab and at their presentations! Good job ladies!

05/17/2016
I'm trying to do Golgi-Cox staining in the Biowave. This sample took 5 1/2 hours from start to finish vs. ~2.5 weeks! No...
04/01/2016

I'm trying to do Golgi-Cox staining in the Biowave. This sample took 5 1/2 hours from start to finish vs. ~2.5 weeks! Now to get the light microscope optimized for taking the higher mag stacks that I need to properly analyze such things!

I have been asked about the dishes we use to process tissue, (both IHC and em processing) in the microwave, so here is t...
02/23/2016

I have been asked about the dishes we use to process tissue, (both IHC and em processing) in the microwave, so here is the info: Kapsto from Poeppelmann (www.poeppelmann.com/us/kapsto). We use the GPN-600B- series. We use different sizes depending on what and how many peices of tissue and they have a huge number of different sizes.

02/10/2016
Ooops, almost missed one
12/31/2015

Ooops, almost missed one

Hope everone enjoyed the holidays! We had a great time seeing some of our past Meshul lab members and catching up with t...
12/31/2015

Hope everone enjoyed the holidays! We had a great time seeing some of our past Meshul lab members and catching up with them. And we missed many of you that were not able to attend. Hopefully, we will see more of you at a future holiday celebration!

12/02/2015

Congratulations to our leader Dr. Charles Meshul for winning the Festival of Lights Neuroscience Research Award!

11/06/2015

Our basic EM procedures can be found in the Notes section

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3710 SW US Veterans Hospital Road R&D 29
Portland, OR
97239

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