Experimental - Practical Area 𝔸𝔾𝕌

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The In Your Element essay from our May issue:

Claire Murray ponders on the attraction benzene — a small, seemingly simple molecule — has long exerted on scientists, some of the insights gained through its exploration, and the varied applications found for this hexagonal ring and its derivatives.

https://www.nature.com/articles/s41557-022-00948-7?utm_source=facebook&utm_medium=social&utm_campaign=nchem ($)

Chương trình trải nghiệm Một ngày là Sinh viên AGU của các bạn Học sinh đến từ trường THPT Vĩnh Bình - Châu Thành - An Giang - 23/3/2025
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Proteins can be described as brilliant chemical tools. They are generally built from 20 amino acids that can be combined in endless ways. Using the information stored in DNA as a blueprint, the amino acids are linked together in our cells to form long strings.

Then the magic of proteins happens: the string of amino acids twists and folds into a distinct – sometimes unique – three-dimensional structure. This structure is what gives proteins their function. Some become chemical building blocks that can create muscles, horns or feathers, while others may become hormones or antibodies. Many of them form enzymes, which drive life’s chemical reactions with astounding precision. The proteins that sit on the surfaces of cells are also important, and function as communication channels between the cell and its surroundings.

It is hardly possible to overstate the potential encompassed by life’s chemical building blocks, these 20 amino acids. The Nobel Prize in Chemistry 2024 is about understanding and mastering them at an entirely new level. One half of the prize goes to Demis Hassabis and John Jumper, who have utilised artificial intelligence to successfully solve a problem that chemists wrestled with for over 50 years: predicting the three-dimensional structure of a protein from a sequence of amino acids. This has allowed them to predict the structure of almost all 200 million known proteins. The other half of the prize is awarded to David Baker. He has developed computerised methods for achieving what many people believed was impossible: creating proteins that did not previously exist and which, in many cases, have entirely new functions.

The 2024 in Chemistry has been awarded with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

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Take a look at the notebook that belonged to the future chemist and Nobel Prize laureate Roger Tsien.

The foundation for our future is laid during childhood. Our view of the world is formed and our interests crystallised in our youth. This is evident in the notebook kept by 2008 chemistry laureate Tsien when he was a child.

The notebook contains lists of countries and major cities and drawings of complicated traffic junctions and famous bridges, which fascinated young Tsien. His father's work in the air force is also reflected in his lists of plane models. Tsien's blossoming interest in chemistry is evident in his lists of basic elements, minerals, vitamins, and medicines, and in the many sketches of chemistry experiments he copied from a book. Tsien's book also includes pages filled with Chinese words, although Tsien says that he found this quite boring.

Photo: A page of sketches of chemistry experiments Tsien copied from a book.

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