Franklin Lab

Excited to share our new “Epigenetic regulation of cardiac physiology and pathophysiology: biological s*x matters” published in Journal of Cardiovascular Aging.

In collaboration with Boudina Lab , Garrido Lab at CSIC– , and Cobo Lab , we highlight how s*x-specific epigenetic mechanisms -including DNA methylation, histone modifications, and non-coding RNAs- shape cardiac development, aging, and cardiovascular disease.

The take-home message: precision cardiovascular medicine must account for biological s*x.

Special kudos to Omid Rouzbehani, who spearheaded the idea and led us through the entire process- great leadership and perseverance.

for a fantastic international .

Epigenetic regulation of cardiac physiology and pathophysiology: biological s*x matters Cardiovascular disease (CVD) is the leading cause of global morbidity and mortality, with epigenetic mechanisms playing a pivotal role in its pathogenesis. This review synthesizes current evidence on s*x-specific epigenetic regulation in cardiac health and disease, highlighting DNA methylation, hist...

Excited to share that our new paper is out in

We investigated the expression and abundance of a specific mark (H4K20me2) and its enzymes across different models of cardiac dysfunction. While global levels didn’t change, we identified several key enzymes that do shift in both mouse models and human tissue.

A small but meaningful step toward understanding how epigenetics shapes .

So to that made this work happen!

Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure Histone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood. Our pr...

Nellie wrapped up her summer research with a fantastic presentation at the Summer Symposium at the , through and ! Big thanks to mentors Drs. Marta Szulik and Sarah Franklin for their support!

Check out our newest contribution to the scientific community!
A result of the fantastic collaboration between Franklin and Selzman labs at CVRTI. The publication describes the first mass-spectrometry based characterization of human acellular amniotic fluid that is cardioprotective against ischemia-reperfusion.
This work is open access so check it out !

Proteomic Characterization of Cardioprotective Human Acellular Amniotic Fluid Amniotic fluid-derived products are a promising resource for cell therapy and tissue engineering due to their anti-inflammatory, angiogenic, and antifibrotic properties. Human amniotic fluid (hAF) has been used in medical applications such as wound healing, skin disorders, and ophthalmic conditions....

Shout out to Bridger Bodily, our undergraduate student researcher from who presented his work last week at the Summer Symposium at the ! And special thanks to Dr. Sarah Franklin, Dr.Marta Szulik, and Ryan Bia for their mentorships!


Sarah Marsing Franklin Marta Sz