09/07/2026
Hemolysis releases free hemoglobin into the plasma, where it rapidly binds and scavenges nitric oxide (NO), a potent endogenous vasodilator. The resulting reduction in nitric oxide bioavailability promotes vasoconstriction, increases systemic and pulmonary vascular resistance, and can impair microvascular perfusion. During cardiopulmonary bypass, excessive hemolysis has also been associated with end-organ dysfunction, including acute kidney injury, making the prevention of red blood cell damage an important goal in perfusion practice.
Reference: https://pmc.ncbi.nlm.nih.gov/articles/PMC3521905/
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