02/20/2026
Today actor Eric Dane (Grey’s Anatomy) passed away after living with Amyotrophic Lateral Sclerosis, a progressive neurodegenerative disease that gradually impairs voluntary movement while awareness and cognition are often preserved.
ALS damages upper and lower motor neurons in the brain and spinal cord. Early symptoms are usually subtle and may initially resemble fatigue or minor orthopedic problems. Patients commonly develop progressive weakness in one limb, hand clumsiness, dropping objects, muscle twitching, slurred speech, or frequent tripping due to foot drop. Sensation typically remains intact, so patients fully perceive the loss of strength.
There is no single confirmatory test. Diagnosis is clinical and supported by neurologic examination showing both upper and lower motor neuron signs, electromyography demonstrating denervation, and imaging and laboratory studies mainly used to exclude other conditions that mimic ALS.
The disease affects about 1 to 2 people per 100,000 each year and most often begins between ages 55 and 75. Around 90 to 95 percent of cases occur sporadically, while a minority are genetic. Median survival is approximately 3 to 5 years, although progression varies among individuals.
There is currently no cure, but treatment slows progression and improves quality of life. Riluzole and edaravone are disease modifying therapies, and respiratory support, nutritional care, and multidisciplinary management significantly prolong survival and comfort.
ALS does not affect consciousness, and patients remain aware throughout the course of the disease.