10/06/2026
According to the CDC, approximately 13% of men will develop prostate cancer.
Although prostate cancer is prevalent, it is not life threatening, with 5-year survival rates near 100%; however, once prostate cancer metastasizes, the 5-year survival rate drops to approximately 34%. Therefore, it is important to understand what imitates prostate cancer metastasis so that better treatments can be developed to prevent metastasis.
A team from Shanghai, China, found that a circular RNA molecule, named circDOPEY2, is overexpressed in prostate cancer and contributes to metastasis. The mechanism of action was identified through a series of knockdown and reconstitution experiments. In short, circDOPEY2 blocks degradation of hnRNPM that then stabilizes ICAM2 mRNA leading to increased expression of ICAM2 protein. Furthermore, the team, and others, demonstrate ICAM2 is involved in metastasis. Additionally, the team found that Serine/Arginine-Rich Splicing Factor 1 (SRSF1) is responsible for generating the circular form of DOPEY2.
Collectively the data provides multiple potential pharmacological targets to prevent prostate cancer metastasis, and circDOPEY2 can be used as a biomarker to track the increased likelihood of prostate cancer metastasis.
Read the research in our recent Editor's Choice: https://ow.ly/OviJ50ZUBUK