The Dr. Mark Noble, Dr. Margot Mayer-Proschel, & Dr. Chris Proschel Lab

Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002583

Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity Different structurally related lipids from three genetically distinct lysosomal storage disorders are sufficient to cause multiple dysfunctions that converge on disruption of lysosomal pH as a core pathogenic mechanism.

4‐Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.

http://embomolmed.embopress.org/content/early/2016/11/14/emmm.201506035 -1

Erythropoietin Enhanced Recovery After Traumatic Nerve Injury: Myelination and Localized Effects.

http://www.sciencedirect.com/science/article/pii/S0363502316304543

www.sciencedirect.com

Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.

http://dx.doi.org/10.1002/glia.22925

Mutation of ataxia–telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia - Campbell - 2015 - Glia - Wiley Online Library Notice: Wiley Online Library will be unavailable on Saturday 26th November 2016 from 07:00-11:00 GMT / 02:00-06:00 EST / 15:00-19:00 SGT for essential maintenance. Apologies for the inconvenience.

A Novel Mouse Model for Ataxia-telangiectasia with a N-terminal Mutation Displays a Behavioral Defect and a Low Incidence of Lymphoma but no Increased Oxidative Burden was published August 26, 2015 in Human Molecular Genetics.

http://www.ncbi.nlm.nih.gov/pubmed/26310626

A novel mouse model for Ataxia-telangiectasia with a N-terminal mutation displays a behavioral... Hum Mol Genet. 2015 Aug 26. pii: ddv342. [Epub ahead of print]

Identifying the Threshold of Iron Deficiency in the Central Nervous System of the Rat by the Auditory Brainstem Response was published January 2015 in ASN Neuro.

http://www.ncbi.nlm.nih.gov/pubmed/25732706

Identifying the threshold of iron deficiency in the central nervous system of the rat by the... ASN Neuro. 2015 Jan-Feb;7(1). doi: 10.1177/1759091415569911. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

cFLIP is Critical for Oligodendrocyte Protection from Inflammation was published Sept 22, 2014 in Cell Death and Differentiation.

http://www.ncbi.nlm.nih.gov/pubmed/25633192

cFLIP is critical for oligodendrocyte protection from inflammation. - PubMed - NCBI Cell Death Differ. 2015 Sep;22(9):1489-501. doi: 10.1038/cdd.2014.237. Epub 2015 Jan 30.

Redox Biology in Normal Cells and Cancer: Restoring Function of the Redox/Fyn/c-Cbl Pathway in Cancer Cells Offers New Approaches to Cancer Treatment was published February 2015 in Free Radical Biology & Medicine. http://www.ncbi.nlm.nih.gov/pubmed/25481740

Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in... Free Radic Biol Med. 2015 Feb;79:300-23. doi: 10.1016/j.freeradbiomed.2014.10.860. Epub 2014 Dec 4. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice was published June 5th 2014 in Environmental Health Perspectives

http://www.ncbi.nlm.nih.gov/pubmed/24901756

Early postnatal exposure to ultrafine particulate matter air pollution: persistent... Environ Health Perspect. 2014 Sep;122(9):939-45. doi: 10.1289/ehp.1307984. Epub 2014 Jun 5. Research Support, N.I.H., Extramural

Margot at TedxFlourCity:

Margot discovered that early pregnancy iron deficiency has a permanent negative effect on a child's intelligence. She explains how easy it would be to treat this deficiency with awareness and foresight and finishes will a call to action for testing and treatment before or early in pregnancy.

http://www.youtube.com/watch?v=PyU0dYxE6D4

Iron Testing Before Pregnancy: Margot Mayer-Proschel at TEDxFlourCity Margot discovered that early pregnancy iron deficiency has a permanent negative effect on a child's intelligence. She explains how easy it would be to treat ...

Gestational Iron Deficiency Differentially Alters the Structure and Function of White and Gray Matter Brain Regions of Developing Rats was published April 17th in J. Nutrition:

http://www.ncbi.nlm.nih.gov/pubmed/24744313

Gestational iron deficiency differentially alters the... [J Nutr. 2014] - PubMed - NCBI PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

An older video but still a great one: Mark presents at TEDxRochester: https://www.youtube.com/watch?v=Gm5NhtdAA9w

TEDxRochester - Mark Noble - 11/7/11 Mark is Professor of Neurology, Genetics, and Neurobiology and Anatomy at University of Rochester School of Medicine and is Director of the University of Roc...