The Dr. Mark Noble, Dr. Margot Mayer-Proschel, & Dr. Chris Proschel Lab

12/19/2016

Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002583

Different structurally related lipids from three genetically distinct lysosomal storage disorders are sufficient to cause multiple dysfunctions that converge on disruption of lysosomal pH as a core pathogenic mechanism.

11/15/2016

4‐Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury.

http://embomolmed.embopress.org/content/early/2016/11/14/emmm.201506035 -1

11/15/2016

Erythropoietin Enhanced Recovery After Traumatic Nerve Injury: Myelination and Localized Effects.

http://www.sciencedirect.com/science/article/pii/S0363502316304543

11/15/2016

Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.

http://dx.doi.org/10.1002/glia.22925

Notice: Wiley Online Library will be unavailable on Saturday 26th November 2016 from 07:00-11:00 GMT / 02:00-06:00 EST / 15:00-19:00 SGT for essential maintenance. Apologies for the inconvenience.

09/04/2015

A Novel Mouse Model for Ataxia-telangiectasia with a N-terminal Mutation Displays a Behavioral Defect and a Low Incidence of Lymphoma but no Increased Oxidative Burden was published August 26, 2015 in Human Molecular Genetics.

http://www.ncbi.nlm.nih.gov/pubmed/26310626

Hum Mol Genet. 2015 Aug 26. pii: ddv342. [Epub ahead of print]

09/04/2015

Identifying the Threshold of Iron Deficiency in the Central Nervous System of the Rat by the Auditory Brainstem Response was published January 2015 in ASN Neuro.

http://www.ncbi.nlm.nih.gov/pubmed/25732706

ASN Neuro. 2015 Jan-Feb;7(1). doi: 10.1177/1759091415569911. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

09/04/2015

cFLIP is Critical for Oligodendrocyte Protection from Inflammation was published Sept 22, 2014 in Cell Death and Differentiation.

http://www.ncbi.nlm.nih.gov/pubmed/25633192

Cell Death Differ. 2015 Sep;22(9):1489-501. doi: 10.1038/cdd.2014.237. Epub 2015 Jan 30.

09/04/2015

Redox Biology in Normal Cells and Cancer: Restoring Function of the Redox/Fyn/c-Cbl Pathway in Cancer Cells Offers New Approaches to Cancer Treatment was published February 2015 in Free Radical Biology & Medicine. http://www.ncbi.nlm.nih.gov/pubmed/25481740

Free Radic Biol Med. 2015 Feb;79:300-23. doi: 10.1016/j.freeradbiomed.2014.10.860. Epub 2014 Dec 4. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

09/04/2015

Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice was published June 5th 2014 in Environmental Health Perspectives

http://www.ncbi.nlm.nih.gov/pubmed/24901756

Environ Health Perspect. 2014 Sep;122(9):939-45. doi: 10.1289/ehp.1307984. Epub 2014 Jun 5. Research Support, N.I.H., Extramural

07/18/2014

Margot at TedxFlourCity:

Margot discovered that early pregnancy iron deficiency has a permanent negative effect on a child's intelligence. She explains how easy it would be to treat this deficiency with awareness and foresight and finishes will a call to action for testing and treatment before or early in pregnancy.

http://www.youtube.com/watch?v=PyU0dYxE6D4

Margot discovered that early pregnancy iron deficiency has a permanent negative effect on a child's intelligence. She explains how easy it would be to treat ...

06/26/2014

Gestational Iron Deficiency Differentially Alters the Structure and Function of White and Gray Matter Brain Regions of Developing Rats was published April 17th in J. Nutrition:

http://www.ncbi.nlm.nih.gov/pubmed/24744313

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

05/29/2014

An older video but still a great one: Mark presents at TEDxRochester: https://www.youtube.com/watch?v=Gm5NhtdAA9w

Mark is Professor of Neurology, Genetics, and Neurobiology and Anatomy at University of Rochester School of Medicine and is Director of the University of Roc...