The Pierce group is a synthetic organic/bio-organic chemistry research lab at NC State under the direction of Prof. Joshua Pierce
07/06/2022
Congrats to Xiang on the total synthesis of bipolamine I, now online in JACS!
Total Synthesis of Bipolamine I Indolizidine alkaloids have been the target of chemical and biological studies for decades, most recently highlighted by the isolation of the curvulamine and bipolamine polypyrrole-containing subclass. Herein we report a stereoselective 15-step synthesis of bipolamine I, a distinct member of the bro...
06/29/2021
Great group event to end last week - retrosynthesis Jeopardy to start the day followed by a group social and new photo! It's fantastic to have everyone back together again.
05/03/2021
Congrats to You-Chen Lin, group PhD #11, on successfully defending his PhD today! Looking forward to watching You-Chen thrive as he moves to the Baran lab at Scripps Research later this summer. Perhaps it's (another) reason to go back and visit La Jolla again...
03/18/2021
Check out our Accounts article for the "Bacterial Multi-Drug Resistance" special issue. It provides an overview of our groups broader interests and some highlights of our recent work.
Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence ConspectusAntimicrobial resistance to existing antibiotics represents one of the greatest threats to human health and is growing at an alarming rate. To further complicate treatment of bacterial infections, many chronic infections are the result of bacterial biofilms that are tolerant to treatment w...
10/23/2020
Congrats to Anna Cholewczynski on successfully defending her PhD today! Group PhD #10 (time flies) - can’t wait to see what she does next!
05/22/2020
Congrats to Dr. Christina Martinez-Brokaw on successfully defending her dissertation this morning! Group PhD #9. Best wishes as you move to Purdue to work as a postdoc in the Parkinson Lab!
05/12/2020
Congrats to You-Chen, Aubert and Yasamin on our ASAP Article in JACS!
Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy Herein, we describe a stereodivergent route to (±)-batzelladine D (2), (+)-batzelladine D (2), (−)-batzelladine D (2), and a series of stereochemical analogues and explore their antimicrobial activity for the first time. The concise synthetic approach enables access to the natural products in a s...
04/02/2020
Great to have such amazing University leadership to see us through rough times!
12/16/2019
Happy Holidays from the Pierce Group!
10/21/2019
Nice view from Sermacs 2019 - a great few days of chemistry too!