We use synthetic biology, directed evolution, protein engineering, and metabolic engineering to prod
10/06/2021
Huge congratulations to Zhongtian Zhang (aka Nemo) who passed his final defense! Dr. Zhang will soon begin work at Amyris. Nemo was a trainee of the Microbiology Graduate Program at NC State. His work involved the identification, characterization, and application of a novel CRISPR-Cas system. Ph.D. #14 for the Williams Group!
04/29/2021
Kudos to Tad Paulsel for being awarded the Department of Chemistry Anderson Award for Teaching!
04/29/2021
Congratulations to Dr. Lexie Malico who recently passed her final Ph.D. defense! Lexie will begin work soon at BASF as part of their professional development program.
04/13/2021
Congratulations to Lindsay Nichols who recently passed her final Ph.D. defense! Lindsay is now a research scientist at Baebies. Ph.D. #12 for the Williams Group!
Congratulations to Anuran Gayen and Miles Calzini for passing their preliminary PhD defense! They are now official PhD candidates!
11/02/2020
Kudos to Williams Lab and Microbiology Graduate Program student Zhongtian Zhang for winning a best poster prize at the LW Parks Lectureship e-symposium!
Leo W. Parks Lectureship Expands In Spite of COVID-19 | Plant and Microbial Biology | NC State University Leo W. Parks Lectureship Expands In Spite of COVID-19 kmpoland Due to the ongoing nature of the COVID-19 Pandemic the LW Parks Lectureship was postponed in March 2020. It was originally planned to have occurred on April 2nd, 2020. Student and faculty organizers for the LW Parks Lectureship put treme...
08/13/2020
We are very grateful to have been selected to receive Chancellors Innovation Funds to advance our genome engineering technology.
2 Sciences Faculty Awarded Chancellor’s Innovation Fund Support Gavin Williams and James Martin, both of the Department of Chemistry, received funding to help bring their innovative research to market.
08/04/2020
Thrilled to share our review article on synthetic biology enabling access to designer polyketides with grad students Alexandra Malico & Lindsay Nichols! Check out Vol 58 of the journal for more synbio articles!
https://authors.elsevier.com/a/1bWE44sz6M8VzF
07/14/2020
Thrilled to announce that grad student Melissa Mitchler will be supported by the National Institutes of Health (NIH) NC State Molecular Biotechnology Training Program Fellowship! Congratulations, Melissa!
04/18/2020
Thrilled to announce another collaborative publication this week - our new paper in Nature Scientific Reports is the result of a collaboration with Phyo Phyo Kyaw Zin and Sean Ekins (Collaborations Pharmaceuticals). MacrolactoneDB is a central repository of macrolactones and their bioactivities. It enables machine learning to inform synthetic biology and medicinal chemistry efforts for designing new/better drugs.
https://www.nature.com/articles/s41598-020-63192-4
04/14/2020
Excited to announce our latest publication and collaboration with the Fourches group at NC State Chemistry, “SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides”. This advance allows in silico libraries of macrolides to be constructed based on the knowledge of polyketide biosynthesis. It’s a first step towards the generation of new bioactive macrolides by combining synthetic biology and computational chemistry.
SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides We report on a new cheminformatics enumeration technology—SIME, synthetic insight-based macrolide enumerator—a new and improved software technology. SIME can enumerate fully assembled macrolides with synthetic feasibility by utilizing the constitutional and structural knowledge extracted from bi...
07/31/2019
This month is the 10-year anniversary of the Williams Lab at NC State Chemistry! I couldn't be prouder of the accomplishments of the current and past undergraduates, graduates, and postdocs of the group!
I hope the next 10 years will be just as successful!