09/07/2026
Researchers tested whether a larger trial would be feasible for studying cannabis oil after knee replacements. This pilot randomized trial tested a 25:1 CBD:THC oral oil formulation compared with placebo in patients undergoing total knee arthroplasty.
Fewer participants in the cannabis oil group reported moderate to severe chronic postsurgical pain at 12 weeks compared with the placebo group. Chronic pain after knee replacement affects a meaningful number of patients, which further supports pain management being an important area for cannabinoid research.
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https://link.springer.com/article/10.1186/s42238-026-00492-y?utm_source=bmc_etoc&utm_medium=email&utm_campaign=CONR_42238_AWA1_GL_DTEC_054CI_TOC-260826
Background Chronic postsurgical pain (CPSP) after total knee arthroplasty (TKA) affects 20% of patients and is associated with higher peri-operative pain. Cannabis products may be effective for reducing CPSP after TKA. We conducted a pilot trial to determine feasibility of a definitive trial assessi...