AAT Bioquest, Inc.

Need a labeled antibody for your next experiment? 🔬

Every project is different, which is why flexibility matters. Whether you're working with an antibody from our catalog or one from your own lab, our custom antibody labeling service is designed to help you get the conjugate you need with reliable, high-quality results.

Here's what you can expect:
✔️ Minimum order of 100 µg
✔️ ≥95% purity guaranteed
✔️ Same-day order fulfillment available for select antibody/label combinations*
✔️ Compatible with both catalog and customer-supplied antibodies

Have questions about your application or label compatibility? We'd be happy to help. Reach out to us at [email protected].

*Availability of 24-hour conjugation service depends on the specific antibody/label pair.

Fluorescence image of CPA 47 cells stained with Phalloidin-iFluor® 555 Conjugate (Cat # 23119) using fluorescence microscope with a Cy3 filter set.

20 years down, and what a celebration it was! 🎉

Take a look through the photos below — this is how we marked two decades of AAT Bioquest! Good food, great company, nonstop laughter, and memories we'll be talking about for years to come. ❤️💙💚

Nothing beats sharing a milestone this big with the incredible team, family, and friends who've been part of this journey with us. From our very first days to who we are today, it's been a ride worth celebrating.

Here's to the memories made, the people who made it all possible, and the next 20 years ahead. 🥂

Together We Shine 💫

New Flyer Alert: Buccutite™ Antibody Labeling Technology

Choosing the right antibody labeling strategy shouldn't be complicated. Our new flyer breaks down how Buccutite™ crosslinking technology gives you three ways to conjugate. Powered by a simple two-reagent system (Buccutite™ MTA + Buccutite™ FOL), it's compatible with protein fluorophores and tandem dyes.

🔹 Lysine Labeling: broad, general-purpose conjugation across accessible amines
🔹 Thiol Labeling: targets the hinge region for more controlled labeling while preserving binding activity
🔹 Fc-Specific Labeling: site-specific conjugation on N-linked glycans for uniform, reproducible results

👉https://docs.aatbio.com/resources/flyers/buccutite.pdf

When it comes to imaging the cytoskeleton, clarity and longevity matter. That's why we're excited to introduce Actin Lightning™ iFluor® 488—a next-generation fluorescent tool engineered for high-affinity staining of filamentous actin (F-actin).

Key features:
✅Formulated to ensure reliable, high-affinity F-actin labeling
✅Maintains signal integrity for approximately one month following staining under appropriate conditions
✅Compatible with fluorescence microscopy workflows for visualizing cell morphology, cytoskeletal organization, and actin filament distribution
✅A high-affinity alternative for researchers currently using Biotium's ActinBrite™, Thermo Fisher's Alexa Fluor Plus phalloidin, or other phalloidin-based staining reagents

Check out this new product:
https://www.aatbio.com/products/actin-lightning-ifluor-488-phalloidin-conjugate

We had an incredible time at ! Can't wait to see you all again next year

Dr. Sonal Patel and Dr. Helen Zhao giving a poster presentation about a unique method to achieve Fc site-specific conjugation that has been successfully used for labeling antibodies with a broad range of target molecules.

Follow the link to learn more!
👉https://docs.aatbio.com/resources/posters/a-new-fc-site-specific-labeling-technology-for-antibody-conjugation-cyto-2026.pdf

This study presents a two-pronged gene therapy approach that simultaneously boosts peak Na⁺ current and Ca²⁺ transient amplitude in cardiomyocytes to combat heart failure. It works by expressing prokaryotic sodium channels (BacNav), which modulate Na⁺/Ca²⁺ exchanger activity and increase sarcoplasmic reticulum calcium stores. In a mouse pressure-overload model of chronic heart failure, AAV9-delivered BacNav therapy rescued contractile deficit, prevented arrhythmias, and improved transcriptomic dysregulation. Our Cal-520 calcium indicator, was used to measure calcium transients in cardiomyocytes—loaded at 10 µM and imaged to track real-time Ca²⁺ dynamics during pacing experiments.

Congrats to Tianwu Yu et al on the publication. Your findings on rescuing cardiac function and preventing arrhythmias in chronic heart failure represent a truly exciting step forward for the field. We are honored that Cal-520 played a role in your research, and it is incredibly rewarding to see our products contribute to work of this caliber. We wish you continued success and look forward to supporting your future discoveries.

Read more
👉 https://www.science.org/doi/full/10.1126/sciadv.ady4551

Learn more about Cal-520 AM
👉 https://www.aatbio.com/products/cal-520-am

Introducing CYTOXite™ Green Dead Cell Stain — a no-wash, mix-and-read dye that lights up only when membrane integrity is lost. Zero background in healthy cells. Bright green signal in dead ones.

Perfect for:
🔬 Cytotoxicity screening
🧬 Membrane integrity studies
📊 Multiplexed cell health assays

Compatible with standard FITC filters (Ex/Em: 491/508 nm) and high-throughput platforms. Works solo or alongside proliferation & apoptosis assays.

Visit the link below to view the full product details, protocol, and SDS:
🔗 https://www.aatbio.com/products/15720