07/23/2026
Angela Yang, a recipient of the Wass Fellowship, is now a co-author on a publication that was done during her fellowship!
The research project Angela participated in involves new, efficient ways to build complex, three‑dimensional sulfur‑containing ring systems that could serve as starting points for future medicines or advanced materials. The team first improved a classic multicomponent reaction (“Sulfo‑Biginelli”) so that simple, commercially available ingredients can be assembled in just a few steps. The resulting “1,2,6‑thiadiazine‑1,1‑dioxides” are highly versatile “platforms” for further chemistry: they undergo selective bond‑forming reactions with other chemical reagents to give fused, bridged, and spirocyclic products, often as single, well‑defined 3D structures. By using chiral catalysts, the team can also bias the reactions to produce predominantly one “handed” version of these molecules, which is important because many biological targets distinguish between left‑ and right‑handed forms. Overall, the work expands the toolbox of synthetic chemistry by turning relatively simple cyclic sulfamides into diverse heterocyclic scaffolds that may be explored later for biological activity.
The Department thanks the Wass Family for supporting our wonderful students!
Read the publication below:
https://pubs.acs.org/doi/10.1021/acs.orglett.6c02685
