08/24/2026
Lithium is a naturally occurring mineral found in foods at concentrations dependent upon the mineral content of the soil. It is also an essential element that people need – in small amounts. High amounts of lithium are toxic.[PMC5696506]
We get roughly 3 -4 mg of lithium per day naturally in our food and water, although this varies depending on where you live and where your food was grown. Lithium orotate is a natural mineral supplement (a salt form of lithium plus orotic acid). It comes in doses ranging from 5 to 10 mg of elemental lithium.
Researchers have looked at areas that have higher levels of lithium in the water and compared them to areas with low lithium levels.
Several studies show that areas with higher lithium levels in their drinking water have lower levels of depression and decreased aggression.
A meta-analysis of studies on lithium in water showed that su***de rates were >50% lower in areas with higher lithium in the drinking water.[PMID: 24072668]
Another study found that homicide rates were lower in areas with higher levels of lithium in the water supply.[PMID: 25556933]
In addition to epidemiological studies showing that lithium in drinking water reduces su***de rates, research on prescription lithium chloride also indicates that it reduces su***de attempts, independent of its effect on mood in bipolar disorder.[PMID: 27852967]
Lithium is thought to act in multiple ways to affect mood:
- alters GSK3B expression, impacting circadian rhythm
- reduces neuroinflammation
- increases BDNF
- interacts with vitamin B12 and folate
1.) Lithium orotate: Impact on circadian rhythm and sleep
One way that lithium interacts with mood is by inhibiting GSK3B (glycogen synthase kinase 3beta). GSK3B acts on many different pathways in the body, including circadian rhythm and neuronal plasticity.[PMID: 28095742]
Dysregulation of GSK3B is linked to bipolar disorder, depression, and Alzheimer’s disease.[PMC3055312]
Lithium competes with magnesium in binding with GSK3B and inhibiting GSK3B. Through its impact on GSK3B, researchers think lithium can modulate the activity of many different pathways, including circadian rhythm. Additionally, lithium may take the place of magnesium in other proteins that need magnesium.[PMC5696506]
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This is just a short excerpt from my in-depth article on Lithium Orotate. Here is the link to my full article: www.geneticlifehacks.com/a-little-lithium-and-b-12-makes-the-world-a-happier-place-for-some/
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