STG lab

And here is another recent one:
https://www.eneuro.org/content/8/6/ENEURO.0338-21.2021

Sorry, we've been bad about updating this page. Here is the latest paper:
https://www.eneuro.org/content/early/2021/11/10/ENEURO.0351-21.2021/tab-article-info

New paper published in Frontiers in Cellular Neuroscience! Nelly Daur, Yang Zhang, Farzan Nadim, and Dirk Bucher show the interactions between central and peripheral spike initiation sites that shape output activity of an STG neuron. The article is part of the Research Topic “Axon Neurobiology”.

Mutual Suppression of Proximal and Distal Axonal Spike Initiation Determines the Output Patterns of a Motor Neuron Axonal spike initiation at sites far from somatodendritic integration occurs in a range of systems, but its contribution to neuronal output activity is not well understood. We studied the interactions of distal and proximal spike initiation in an unmyelinated motor axon of the stomatogastric nervous...

New Paper in eLife! Diana Martinez, Haroon Anwar, Dirk Bucher, and Farzan Nadim, in collaboration with Amit Bose from the NJIT Math Department, show how the shape of synaptic input can help to maintain the activity phase of a neuron across different frequencies of rhythmic activity.
Author manuscript is now available here:

Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network In oscillatory systems, neuronal activity phase is often independent of network frequency. Such phase maintenance requires adjustment of synaptic input with network frequency, a relationship that we explored using the crab, Cancer borealis, pyloric network. The burst phase of pyloric neurons is rela...

Congratulations to Eve!

Eve Marder Known as one of the most influential neuroscientists of her generation, Marder’s research over more than 40 years has provided transformative insight into the fundamental processes of animal and human brains.

Lily Li, Dirk Bucher, and Farzan Nadim's paper about distinct rules for co-modulation of neurons and synapses is in the latest issue of the Journal of Neuroscience:
http://www.jneurosci.org/content/38/40/8549.long

Not only that, it is also a featured article, highlighted in the "This Week in The Journal" section:
http://www.jneurosci.org/content/38/40/i

Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators Multiple neuromodulators act in concert to shape the properties of neural circuits. Different neuromodulators usually activate distinct receptors but can have overlapping targets. Therefore, circuit output depends on neuromodulator interactions at shared targets, a poorly understood process. We expl...

Our very own Farzan Nadim is the recipient of the 2018 NJIT Excellence in Research Prize and Medal.

FARZAN NADIM 2018 NJIT Excellence in Research Prize and Medal Dr Farzan Nadim has been awarded the NJIT Excellence in Research Prize and Medal for his work as Professor of Neurobiology and Director of the Institute of B...

New work on neuropeptide co-modulation in the STG: Xinping Li's thesis work shows that neuromodulatory effects on synapses are linearly additive, but effects on voltage-gated ion channels are not... manuscript uploaded to bioRxiv:

Distinct co-modulation rules of synaptic and voltage-gated currents coordinates interactions of multiple neuromodulators Different neuromodulators usually activate distinct receptors but can have overlapping targets. Consequently, circuit output depends on neuromodulator interactions at shared targets, a poorly understood process. We explored quantitative rules of co-modulation of two principal targets: voltage-gated....

Farzan Nadim and Dirk Bucher just got awarded a 5 year R01 grant renewal from the National Institute of Mental Health, "Neuromodulation of Neuronal Oscillations". The objective is to study co-modulatory effects of neuropeptides on neuron, synapse, and circuit function.

New paper from a collaboration with the Bose Group from the NJIT Math Department:

Phase-locking and bistability in neuronal networks with synaptic depression We consider a recurrent network of two oscillatory neurons that are coupled with inhibitory synapses. We use the phase response curves of the neurons …

Social media highlight of our Journal of Neurophysiology article with the Schulz lab.

In this new study published in our special collection on central pattern generators, the authors "demonstrate that neurons of the crustacean stomatogastric ganglion generate apparent compensatory responses to loss of peptide neuromodulation, adding to the repertoire of mechanisms by which the stomatogastric nervous system can regulate and stabilize its own output." Check it out here: https://doi.org/10.1152/jn.00383.2017

Our long-term collaborator and good friend Horacio G. Rotstein moved from NJIT Math to our Department of Biological Sciences. Horacio is a Full Professor who, among other things, employs theoretical and computational approaches to understand the principles underlying many different forms of oscillations, from rhythmic motor patterns in the STG to cortical oscillations. In the last few years, he spent a major share of his time hanging out in our offices, anyway, so it's great that he's officially moving in. Welcome Horacio!