09/07/2024
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09/07/2024
A 66-year-old man who was recently diagnosed with Parkinson disease comes to the physician for a follow-up
examination. Carbidopa-levodopa therapy was initiated at the time of diagnosis. The patient tells the physician that he
still has episodes during which he "freezes." He has a clumsy gait, and there is rigidity of his upper extremities and
hands. An adjunct therapy designed to inhibit which of the following enzymes is most likely indicated in this patient?
(A) Aromatic L-amino acid decarboxylase
(B) Dopamine ฮฒ-hydroxylase
(C) Monoamine oxidase B
(D) Phenylethanolamine N-methyltransferase
(E) Tyrosine hydroxylase