University of Minnesota MSTP (MD/PhD)

Learn about the University of Minnesota MSTP (MD/PhD), which is dedicated to training future leaders in scientific discovery and clinical medicine.

03/15/2024

We are excited to share with you the MSTP's Match Day 2024 results. Congratulations!! We are so proud of you!

Sara Bolivar Wagers, PhD
Children's Hospital of Philadelphia - Pediatrics (PSTP)

Dieter Brandner, PhD
University of California - San Francisco - Opthalmology

Julie Brekke-Riedl, PhD
Brown University - Psychiatry

Alexander Dwyer, PhD
Johns Hopkins Hospital - Otolaryngology

Robin Lee, PhD
University of Minnesota - Internal Medicine (PSTP)

Stephanie Rhee, PhD
Mayo Clinic - Diagnostic Radiology

Megan Schmit, PhD
University of Minnesota - Pediatrics (PSTP)

Javier Sierra Pagan, PhD
University of Pennsylvania - Internal Medicine (PSTP)

Philip Titcombe, PhD
Yale University - Internal Medicine (Physician Scientist)

Brian Trieu, PhD
Mayo Clinic - Psychiatry

Kelsey Wanhainen, PhD
UCLA - Internal Medicine

Prevalence and quality of medical Spanish education in US osteopathic medical schools: a national survey - PubMed 03/06/2024

Check out the co-author paper from Sinibaldo Romero Arocha in Journal of Osteopathic Medicine titled "Prevalence and quality of medical Spanish education in US osteopathic medical schools: a national survey."

Prevalence and quality of medical Spanish education in US osteopathic medical schools: a national survey - PubMed Most osteopathic schools provide medical Spanish education, but work is needed to improve consistency, quality, and sustainability. Future research should focus on osteopathic student language proficiency assessment, improve medical Spanish accessibility for students at rural programs, and explore t...

Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes - PubMed 03/05/2024

Check out the co-author paper from John Lozada in Prostate Cancer and Postatic Diseases titled "Natural killer cell infiltration in prostate cancers predict improved patient outcomes."

Natural Killer Cell Infiltration in Prostate Cancers Predict Improved Patient Outcomes - PubMed Using the largest available dataset to date, we demonstrated that NK cells infiltrate a broad range of tumors, including both primary and metastatic PCa. NK cell infiltration is associated with improved PCa patient outcomes. This study demonstrates that NK cells are capable of trafficking to both pr...

Rural-urban differences in meeting of physical activity recommendations by sun exposure and protection behaviors in the United States - PubMed 03/04/2024

Check out the first author paper from Allison Dona in Prevention Medicine titled "Rural-urban differences in meeting of physical activity recommendations by sun exposure and protection behaviors in the United States."

Rural-urban differences in meeting of physical activity recommendations by sun exposure and protection behaviors in the United States - PubMed Meeting PA recommendations was associated with greater sun exposure in both rural and urban populations. Additional exercise location (indoors/outside) data is needed to inform PA and skin cancer prevention interventions to reduce unintended increases in sun exposure and reductions in PA, respective...

Characteristics and co-morbidities associated with hospital discharges for opioid and methamphetamine co-use, United States 2016-2019 - PubMed 02/20/2024

Check out the first author paper from Riley Shearer in Drug Alcohol and Dependence Reports titled "Characteristics and co-morbidities associated with hospital discharges for opioid and methamphetamine co-use, United States 2016-2019."

Characteristics and co-morbidities associated with hospital discharges for opioid and methamphetamine co-use, United States 2016-2019 - PubMed Patients discharged with co-use differ from patients with opioid or methamphetamine use alone, representing a range of challenges and opportunities. In addition to offering treatment for both substance use disorders, hospital-based services that address co-occurring conditions may better support pat...

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts - PubMed 02/19/2024

Check out the co-author paper from Hannah Bergom in Molecular Cancer Research titled "Unraveling the global proteome and phosphoproteome of prostate cancer patient-derived xenografts."

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts - PubMed Resistance to androgen deprivation therapies leads to metastatic castration-resistant prostate cancer (mCRPC) of adenocarcinoma (AdCa) origin that can transform to emergent aggressive variant prostate cancer (AVPC) which has neuroendocrine (NE)-like features. In this work, we used LuCaP patient-deri...

Providers' Experiences and Perspectives in Treating Patients With Co-Occurring Opioid and Stimulant Use Disorders in the Hospital - PubMed 01/31/2024

Check out the first author paper from Riley Shearer in Substance Abuse titled "Providers’ experiences and perspectives treating patients with co-occurring opioid and stimulant use disorders in the hospital."

Providers' Experiences and Perspectives in Treating Patients With Co-Occurring Opioid and Stimulant Use Disorders in the Hospital - PubMed We identified unique challenges providing hospital addiction medicine care to patients who use both opioids and stimulants. These findings inform the development, implementation, and testing of hospital-based interventions for patients with co-use.

A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells - PubMed 01/30/2024

Check out the first author paper from Megan Schmit in Open Biology titled "A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells."

A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells - PubMed Natural killer (NK) cell deficiency (NKD) is a rare disease in which NK cell function is reduced, leaving affected individuals susceptible to repeated viral infections and cancer. Recently, a patient with NKD was identified carrying compound heterozygous variants of MCM10 (minichromosome m...

Divergent immune microenvironments in two tumor nodules from a patient with mismatch repair-deficient prostate cancer - PubMed 01/29/2024

Check out the first author paper from Hannah Bergom and co author paper from John Lozada in NPJ Genomic Medicine titled "Divergent immune microenvironments in two tumor nodules from a patient with mismatch repair-deficient prostate cancer."

Divergent immune microenvironments in two tumor nodules from a patient with mismatch repair-deficient prostate cancer - PubMed Patients with prostate cancer (PC) generally do not respond favorably to immune checkpoint inhibitors, which may be due to a low abundance of tumor-infiltrating lymphocytes even when mutational load is high. Here, we identified a patient who presented with high-grade primary prostate cancer with two...

Utility of Cerebrospinal Fluid Protein Levels as a Potential Predictive Biomarker of Disease Severity in HIV-Associated Cryptococcal Meningitis - PubMed 01/19/2024

Check out the co-author preprint from Liz Okafor in medRxiv titled "Utility of cerebrospinal fluid protein levels as a potential predictive biomarker of disease severity in HIV-associated cryptococcal meningitis."

Utility of Cerebrospinal Fluid Protein Levels as a Potential Predictive Biomarker of Disease Severity in HIV-Associated Cryptococcal Meningitis - PubMed In cryptococcal meningitis, individuals with CSF protein ≥100 mg/dL more frequently presented with seizures, altered mental status, immune activation, and favourable fungal outcomes. Baseline CSF protein levels may serve as a surrogate marker of immune activation and prognosis.

Metabolic Changes during In Vivo Maturation of PSC-Derived Skeletal Myogenic Progenitors - PubMed 01/18/2024

Check out the co-author paper from Bayardo Garay in Cells titled "Metabolic changes during in vivo maturation of PSC-derived skeletal myogenic progenitors."

Metabolic Changes during In Vivo Maturation of PSC-Derived Skeletal Myogenic Progenitors - PubMed In vitro-generated pluripotent stem cell (PSC)-derived Pax3-induced (iPax3) myogenic progenitors display an embryonic transcriptional signature, but upon engraftment, the profile of re-isolated iPax3 donor-derived satellite cells changes toward similarity with postnatal satellite cells, suggesting t...

01/17/2024

We welcome the 5th group of candidates visiting our program.

A Low-Cost, Tabletop LOD-EPR System for Nondestructive Quantification of Iron Oxide Nanoparticles in Tissues - PubMed 01/16/2024

Check out the first author paper from Saurin Kantesaria in ACS Sensors titled "A low-cost, tabletop LOD-EPR system for nondestructive quantification of iron oxide nanoparticles in tissues."

A Low-Cost, Tabletop LOD-EPR System for Nondestructive Quantification of Iron Oxide Nanoparticles in Tissues - PubMed Iron oxide nanoparticles (IONPs) have wide utility in applications from drug delivery to the rewarming of cryopreserved tissues. Due to the complex behavior of IONPs (e.g., uneven particle distribution and aggregation), further developments and clinical translation can be accelerated by having acces...

01/12/2024

Congratulations to Riley Shearer, who successfully defended his PhD. The title of his thesis is "Characteristics and outcomes for hospitalized patients with methamphetamine and opioid co-use: Identifying opportunities for hospital-based addiction services tailored to co-use".

Racial and Ethnic Differences in He**in, Methamphetamine, and Co***ne Use, Treatment, and Mortality Trends in 3 National Data Sources-United States, 2010-2019 - PubMed 01/08/2024

Check out the first author paper from Riley Shearer in Medical Care titled "Racial and ethnic differences in he**in, methamphetamine, and co***ne use, treatment, and mortality trends in 3 national data sources-United States, 2010-2019".

Racial and Ethnic Differences in He**in, Methamphetamine, and Co***ne Use, Treatment, and Mortality Trends in 3 National Data Sources-United States, 2010-2019 - PubMed Substance use, treatment, and overdose mortality changed considerably, though not always equivalently. Identifying diverging trends in substance-related measures for specific substances and racial and ethnic groups can inform targeted investment in treatment to reduce disparities and respond to emer...

Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis - PubMed 01/02/2024

Check out the co-author paper from Liz Okafor in Frontiers in Immunology titled "Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis".

Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis - PubMed Survivors of both genders demonstrated a significant increase in the levels of immune regulatory IL-10. In conclusion, the lower survival among women with CM was accompanied by distinct differential gender-specific neuroimmune signatures. These female and male intragender-specific survival-associate...

12/23/2023

Discovery creates better care. Our 2023 Annual Report highlights a sample of the partnerships, discoveries, and solutions we are proud and grateful to be a part of: ar.med.umn.edu.

12/14/2023

We welcome the 4th group of candidates visiting our program.

Long-lasting household damage from Cyclone Idai increases malaria risk in rural western Mozambique - PubMed 12/11/2023

Check out the co-author paper from Dominique Earland in Science Reports titled "Long-lasting household damage from Cyclone Idai increases malaria risk in rural western Mozambique".

Long-lasting household damage from Cyclone Idai increases malaria risk in rural western Mozambique - PubMed Cyclone Idai in 2019 was one of the worst tropical cyclones recorded in the Southern Hemisphere. The storm caused catastrophic damage and led to a humanitarian crisis in Mozambique. The affected population suffered a cholera epidemic on top of housing and infrastructure damage and loss of life. The....

12/08/2023

Congratulations to Adrine Kocharian, who successfully defended her PhD. The title of her thesis is "Dopaminergic control of neuroeconomic decision-making".

Understanding Regional Patterns of Overdose Deaths Related to Opioids and Psychostimulants - PubMed 12/05/2023

Check out the co-author paper from Riley Shearer in Substance Use Misuse titled "Understanding regional patterns of overdose deaths related to opioids and psychostimulants".

Understanding Regional Patterns of Overdose Deaths Related to Opioids and Psychostimulants - PubMed Our results illustrated the heterogenous geographic distribution of the growing concurrent opioid and psychostimulant overdose crisis. The substantial regional variation we identified highlights the need for local data to guide policymaking and treatment planning. The association of opioid-psychosti...

Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI - PubMed 12/04/2023

Check out the co-author paper from Rebecca Butler in Frontiers in Neurology titled "Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI".

Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI - PubMed Active DBS contact proximity to the CTT was associated with lower therapeutic current requirement following DBS surgery for ET, but therapeutic current was increased over time. Distance to CTT did not predict the need for increased current over time, or longer term post-operative tremor control in t...

Jenna Dick 11/22/2023

Jenna Dick's 3MT presentation

Jenna Dick Jenna Dick, 2023 Three-Minute Thesis Competition at the University of Minnesota.

Rebecca Butler 11/21/2023

Rebecca Butler's 3MT presentation

Rebecca Butler Rebecca Butler, 2023 Three-Minute Thesis Competition at the University of Minnesota.

11/21/2023

We welcome the 3rd group of candidates visiting our program.

Minnesota Data Sharing May Be Model For Near-Real-Time Tracking Of Drug Overdose Hospital And ED Trends - PubMed 11/15/2023

Check out the first author paper from Riley Shearer in Health Affairs titled "Minnesota data sharing may be model for near-real-time tracking of drug overdose hospital and ED trends".

Minnesota Data Sharing May Be Model For Near-Real-Time Tracking Of Drug Overdose Hospital And ED Trends - PubMed The drug overdose epidemic in the US necessitates detailed and timely data to inform public health responses. In this article we describe how an electronic health record (EHR) data-sharing collaboration across health systems in Minnesota that was developed in response to the COVID-19 pandemic was ad...

NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics? - PubMed 11/13/2023

Check out the co-author review from Jenna Dick in Frontiers in Immunology titled "NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics?"

NK cell subsets and dysfunction during viral infection: a new avenue for therapeutics? - PubMed In the setting of viral challenge, natural killer (NK) cells play an important role as an early immune responder against infection. During this response, significant changes in the NK cell population occur, particularly in terms of their frequency, location, and subtype prevalence. In this review, c...

Photos from University of Minnesota MSTP (MD/PhD)'s post 11/10/2023

Congratulations to Rebecca Butler and Jenna Dick for representing College of Science and Engineering, and the Medical School in today's Unversity-wide Three Minute Thesis Competition.

11/02/2023

We welcome the second group of candidates visiting our program

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420 Delaware Street SE
Minneapolis, MN
55455
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