Environmental Health Sciences

https://www.technologynetworks.com/genomics/news/genes-linking-alzheimers-and-down-syndrome-discovered-305399?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=64032492&_hsenc=p2ANqtz-9WlvFmkdWXQuRN2TCAs2nA0P2ZL7u_1rW6TowbJRMdA_wWUjp2YmiZg9KpQiSFqdQS60HhBmVOQWK4D5qDID75r0CQuA&_hsmi=64032492

Genes Linking Alzheimer’s and Down Syndrome Discovered

Congratulations to Drs Chao, Hu (visiting fellows in the Oxidative Stress Group), and Cooke, on the acceptance of the paper on cellular and urinary DNA adductomics in Archives of Toxicology:

Chang, Y-J., Cooke, MS., Hu, C-W. and Chao, M-R. Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures. Archives of Toxicology. (In press.).

https://www.nature.com/articles/d41586-018-05255-1

Fifty years since DNA repair was linked to cancer In 1968, a defect in DNA repair was found to underlie a disorder that makes people extremely sensitive to sunlight. This finding continues to influence research into the origins, diagnosis and treatment of cancer.

https://www.technologynetworks.com/neuroscience/news/exosomes-involved-in-spread-of-alzheimers-pathology-305071?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63756529&_hsenc=p2ANqtz-8x5ffJCjZGQLmQgq2S1mTtqG2dzOep_TeP2qt0SV2e63pQfG2v5IeQ5VOsi1ENEUHhZYBiJADSi7389n5hRPP5WTIcQQ&_hsmi=63756529

Scientists Uncover How Alzheimer's Spreads Throughout the Brain Exosomes can contain amyloid-beta oligomers, which other cells can absorb.

https://www.technologynetworks.com/drug-discovery/news/new-ovarian-cancer-target-305059?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63756529&_hsenc=p2ANqtz-8x5ffJCjZGQLmQgq2S1mTtqG2dzOep_TeP2qt0SV2e63pQfG2v5IeQ5VOsi1ENEUHhZYBiJADSi7389n5hRPP5WTIcQQ&_hsmi=63756529

New Ovarian Cancer Target Researchers have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer. This new study opens a potential avenue for treating ovarian cancer. Since Calcit...

https://www.technologynetworks.com/neuroscience/news/mechanism-by-which-alpha-synuclein-causes-cell-death-in-parkinsons-identified-305013?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63721315&_hsenc=p2ANqtz-9U5Q93Dnyt8A9uxfFDcZYrT_JbKGKnNOLHzBDxRLCO69JZfAu9isQtfByB6ISrfDuV5khwAjIIqMkBTmU1kCXq96D1tw&_hsmi=63721315

Molecular Pathway to Cell Death in Parkinson's Identified, Reveals New Therapeutic Target Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease.

https://www.technologynetworks.com/cancer-research/news/study-identifies-cellular-death-code-304908?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63648751&_hsenc=p2ANqtz-8zBrSCAF0J16KmurOwLt9FkBIFyGQYXc_ZBiqIpesjYfkHXlWpGoxFxSTJ8ED6f9KjdC0vXPMc6YjU8KoLQ2uK2VHVaA&_hsmi=63648751

Study Identifies Cellular ‘Death Code’ Dying cells generally have two options: go quietly, or go out with a bang. The latter, while more conspicuous, is also mechanistically more mysterious. Now, scientists have pinpointed what they believe is the molecular

https://www.technologynetworks.com/cancer-research/news/telomerase-highest-level-of-detail-ever-seen-304781?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63575853&_hsenc=p2ANqtz-9f5bQ9qR441-ncJf_JPhBq2iLT3QhFwjdm9hBJElL7Cqg7lAB_dKmsCnW_MsTTDij8I2YBi3a-OfTtITHMqRiHT4_NIw&_hsmi=63575853

Telomerase: Highest Level of Detail Ever Seen Researchers report the deepest scientific understanding yet of this once-mysterious enzyme, whose catalytic core -- where most of its activity occurs -- can now be seen in near atomic resolution. Telomerase is especially active in cancer cells, which enables cancer to grow and spread.

https://www.technologynetworks.com/biopharma/news/antibody-shrinks-tumors-of-patients-with-advanced-skin-cancer-304710?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63500679&_hsenc=p2ANqtz--ATAIe0GBID_cq1IA8DRsi53ULrbo5xgWyF5bb1G7z4tscabYQ3D3fwK8t-Q6NNIY-RjugawkQQqUq81JTd9Bz-vaSwQ&_hsmi=63500679

Antibody Shrinks Tumors of Patients with Advanced Skin Cancer Clinical trials show that an immune checkpoint inhibitor shrinks the tumors of nearly half of patients with an incurable, advanced form of a common skin cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117380/

Skin β-endorphin mediates addiction to ultraviolet light Ultraviolet light is an established carcinogen yet evidence suggests that UV-seeking behavior has addictive features. Following UV exposure, epidermal keratinocytes synthesize Proopiomelanocortin that is processed to Melanocyte Stimulating Hormone, inducing ...

https://journals.lww.com/eurjcancerprev/Abstract/2018/03000/Coffee_consumption_and_risk_of_nonmelanoma_skin.10.aspx

Coffee consumption and risk of nonmelanoma skin cancer: a... : European Journal of Cancer Prevention ffee intake and the risk of nonmelanoma skin cancer. Studies were identified by searching the PubMed and MEDLINE databases (to November 2015). Study-specific risk estimates were pooled under the random-effects model. We separately estimated the relative risk of the three conditions, for exposure to....

www.pnas.org/content/111/16/5773.long

Rescuing US biomedical research from its systemic flaws The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession—and making it difficult for seasoned investigators to prod...