UAMS Donald W. Reynolds Institute on Aging

UAMS Donald W. Reynolds Institute on Aging This is the official page for the University of Arkansas for Medical Sciences Donald W. Reynolds Institute on Aging Department of Geriatrics.

Our mission is clinical care, education, and research. Established through a $28.8 million gift from the Donald W. Reynolds Foundation, the Reynolds Institute on Aging recognizes that the focus of health care must shift from merely keeping people alive to making those later years healthier and more productive. In other words, the focus is not adding years to life; rather, it’s adding life to years. Through the generosity of the Reynolds Foundation in providing an additional $33.4 million gift in 2009, we are poised to expand our services, continuing our tradition of providing world-class medical care to the citizens of Arkansas. Our patient services include the Thomas and Lyon Longevity clinic, Walker Family Memory center, Housecall program and Palliative Care program.

Learning, connection, and the wisdom of generations came together at Presbyterian Village We were thrilled to welcome me...
09/24/2026

Learning, connection, and the wisdom of generations came together at Presbyterian Village

We were thrilled to welcome medical students, PA students, internal and family medicine residents, pharmacy student and geriatrics fellows as they joined us in caring for older adults in inter professional learning at nursing home and rehabilitation settings.

One of the greatest joys of geriatrics is watching learning flow both ways. Our trainees gain invaluable wisdom from residents, while our older adults share their stories, experiences, and perspectives with the next generation of healthcare professionals.

A special thank you to Dr. Mendiratta, Medical Director and preceptor, and Janet Rader, PA student preceptor, for their dedication to mentorship and education in the presbyterian village.

We are grateful for these meaningful connections and for the older adults who continue to be among our greatest teachers. ❤️

Donald W. Reynolds was born on this day in 1906, in Fort Worth, Texas. His family moved to Oklahoma City shortly after h...
09/23/2026

Donald W. Reynolds was born on this day in 1906, in Fort Worth, Texas.

His family moved to Oklahoma City shortly after his birth. He became a businessman at the age of 12, buying copies of The Oklahoma Times for a half penny, then selling them for a penny.

After graduating high school, he attended the University of Missouri's School of Journalism. Graduating in 1927, he was fired from his first two newspaper jobs, then hired by the Austin American-Statesman. While there, he became part owner in a small photo-engraving plant.

In 1934, he worked for the United Press in Europe, accompanying the Italian Army as they fought in the Second Italo-Ethiopian War. When he returned to the U.S. in 1936, he bought an interest in the Quincy Evening News in Massachusetts. He profited a year later when the paper was paper was acquired by the Quincy Patriot Ledger.

He invested in two other papers in 1938, but one went bankrupt and the other ceased operations due to competition.

In 1940, he purchased the Fort Smith Times, Southwest American, and the Okmulgee Daily Times - and the Donrey Media Group was born.

He fought in the Second World War, winning a Purple Heart after his reconnaissance plane was hit by a German shell, wounding him in the face, neck, and shoulders. He was discharged in February 1945.

Less than ten years later, Donald Reynolds founded the Donald W. Reynolds Foundation. Initially, the Foundation awarded $100,000 in scholarships each year to journalism students at 10 universities. The Foundation was created to support needs and to make a "transformational impact" (Little Rock Soirée magazine, 10/1/09) in four areas:

1) Meet the greatest needs in Arkansas, Nevada, and Oklahoma through improved facilities for their outstanding nonprofits.
2) Accelerate the fight against atherosclerosis and atherosclerotic heart disease through cutting-edge, translational research.
3) Improve the quality of life of America's growing elderly population through better training of physicians in geriatrics.
4) Enhance the quality and integrity of journalism, focusing particularly on better training of journalists who serve smaller communities and on business journalism.

Before the Foundation closed in 2005, it had made a significant impact across the three states above, but particularly Arkansas. It is through this generosity that the UAMS Donald W. Reynolds Institute on Aging was created.

Donald W. Reynolds retired in 1990, and passed away on April 2, 1993, on a ship in the Mediterranean. At the time of his death, he owned 53 daily newspapers, 11 outdoor advertising companies, five cable television companies, and one television station. He was survived by his wife, three children, and six grandchildren.

On this episode of The Wei to Wellness, Dr. Wei answers a viewer's question about LP(a) cholesterol tests. Be sure to wa...
09/17/2026

On this episode of The Wei to Wellness, Dr. Wei answers a viewer's question about LP(a) cholesterol tests.

Be sure to watch weekly, as host Nichole Niemann sits down with Dr. Wei to discuss timely health topics.

Dr. Jeanne Wei is a triple-board certified M.D. and Ph.D. She is the Executive Director of the UAMS Donald W. Reynolds Institute on Aging and the Chair of the Reynolds Department of Geriatrics.

UAMS cardiologist Dr. Jeanne Wei answers a viewer's question.

Just a reminder, our Geriatrics Updates Conference is quickly approaching!
09/16/2026

Just a reminder, our Geriatrics Updates Conference is quickly approaching!

The University of Arkansas for Medical Sciences (UAMS) will host its 2026 Geriatrics Updates conference Oct. 1-3, providing an opportunity for health professionals, patients, caregivers, and community members to learn about the latest developments in research and clinical care for older adults.

On this episode of The Wei to Wellness, Dr. Wei gives us insight into adding a fiber supplement to your day. Be sure to ...
09/14/2026

On this episode of The Wei to Wellness, Dr. Wei gives us insight into adding a fiber supplement to your day.

Be sure to watch weekly, as host Nichole Niemann sits down with Dr. Wei to discuss timely health topics.

Dr. Jeanne Wei is a triple-board certified M.D. and Ph.D. She is the Executive Director of the UAMS Donald W. Reynolds Institute on Aging and the Chair of the Reynolds Department of Geriatrics.

UAMS cardiologist, Dr. Jeanne Wei, discusses the benefits of adding Metamucil to your diet.

In this week's episode of The Wei to Wellness, Dr. Jeanne Wei discusses Dolly Parton. Be sure to watch weekly, as host N...
09/10/2026

In this week's episode of The Wei to Wellness, Dr. Jeanne Wei discusses Dolly Parton.

Be sure to watch weekly, as host Nichole Niemann sits down with Dr. Wei to discuss timely health topics.

Dr. Jeanne Wei is a triple-board certified M.D. and Ph.D. She is the Executive Director of the UAMS Donald W. Reynolds Institute on Aging and the Chair of the Reynolds Department of Geriatrics.

UAMS cardiologist, Dr. Jeanne Wei, discusses the life and passing of Dolly Parton.

We are excited to welcome Dr. Namrata Dogra and Dr. Benjamin Frazier to the Thomas and Lyon Longevity Clinic!
09/09/2026

We are excited to welcome Dr. Namrata Dogra and Dr. Benjamin Frazier to the Thomas and Lyon Longevity Clinic!

The University of Arkansas for Medical Sciences (UAMS) has welcomed Namrata Dogra, M.D., and Benjamin Frazier, M.D., as new physicians at the Thomas and Lyon Longevity Clinic in the UAMS Donald W. Reynolds Institute on Aging.

Congratulations to Dr. Jeanne Wei for being selected by Little Rock Soirée magazine as a Little Rock Top Doc 2026 in the...
08/31/2026

Congratulations to Dr. Jeanne Wei for being selected by Little Rock Soirée magazine as a Little Rock Top Doc 2026 in the field of cardiology!

On this episode of The Wei to Wellness, Dr. Jeanne Wei discusses maternal mental health. Be sure to watch weekly, as hos...
08/27/2026

On this episode of The Wei to Wellness, Dr. Jeanne Wei discusses maternal mental health.

Be sure to watch weekly, as host Nichole Niemann sits down with Dr. Wei to discuss timely health topics.

Dr. Jeanne Wei is a triple-board certified M.D. and Ph.D. She is the Executive Director of the UAMS Donald W. Reynolds Institute on Aging and the Chair of the Reynolds Department of Geriatrics.

UAMS cardiologist, Dr. Jeanne Wei, discusses postpartum depression and psychosis.

Computational Drug Discovery Leads to Experimental Validation of a Potential Alzheimer’s Therapeutic StrategyOne of our ...
08/24/2026

Computational Drug Discovery Leads to Experimental Validation of a Potential Alzheimer’s Therapeutic Strategy

One of our Reynolds Institute on Aging researchers, Dr. Meenakshisundaram Balasubramaniam recently collaborated with a researcher at Harvard on this discovery. All computational predictions were performed by Dr. Balasubramaniam at UAMS.

Article Title: Zolpidem restores sleep and decreases amyloid in a mouse model Yu L, Yokomizo S, Doan TH, Zhao Q, Ganne A, Balasubramaniam M, Kastanenka KV. Zolpidem restores sleep and decreases amyloid in a mouse model. Alzheimers Dement. 2026 Mar;22(3):e71175. doi: 10.1002/alz.71175. PMID: 41810694; PMCID: PMC12976976.

Link: https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71175

A key strength of this study was the integration of advanced computational drug-discovery approaches by Dr. Balasubramaniam with rigorous in vivo experimental validation by Dr. Kastanenka at Harvard Medical School. The computational component employed an unbiased screening strategy to search approximately 2,300 FDA-approved drugs for compounds capable of modulating the GABAA receptor, an important regulator of inhibitory neuronal signaling and sleep. The workflow combined structure-based high-throughput virtual screening, molecular mechanics–based binding free-energy calculations, machine learning and neural-network classification, and molecular dynamics simulations of the intact GABAA receptor embedded within a virtual lipid membrane. This multistep strategy identified zolpidem as a leading candidate and further predicted that its interaction with the receptor could facilitate chloride-ion transport, providing a structural and mechanistic rationale for enhancing GABAergic signaling and restoring sleep-associated neuronal activity.
Importantly, these computational predictions were subsequently validated experimentally in Dr. Kastanenka’s lab at the MassGeneral Institute of Neurodegenerative Diseases and Harvard Medical School using an Alzheimer’s disease mouse model. The experimental studies demonstrated that zolpidem improved NREM sleep stability, restored the sleep-dependent cortical slow oscillations predicted to benefit neuronal function, and, following chronic treatment, significantly reduced cortical amyloid plaque burden and neuronal calcium overload. Zolpidem treatment also improved sleep-dependent contextual memory without adversely affecting locomotor activity. Together, the study demonstrates the power of integrating computational drug repurposing with experimental neuroscience: computational modeling identified and mechanistically prioritized a clinically available compound, while independent in vivo studies provided biological validation that the predicted intervention could improve sleep-associated brain function and reduce key Alzheimer’s disease–related pathologies.

INTRODUCTION Deficits in non–rapid eye movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing gamma-aminobutyric acid-ergic (GABAergic) signaling can restore sleep. Unbiase...

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