ExchangeCME

🔬 Save the Date: IL-33 in the SpotlightJoin us at ATS 2026 for an expert-led discussion on emerging IL-33 pathways and their role in COPD and acute respiratory infections.📍 Hilton Orlando (Florida Ballroom 1–4)
🗓 Monday, May 18
⏰ 6:30 – 8:30 PM ET🎓 Earn 1.5 CME credits
🍽 Dinner will be servedFaculty:
• Jonathan M. Hand, MD
• Dave Singh, MD
• Tom Wilkinson, MA, MBBS, PhD
Explore novel mechanisms and evolving clinical implications shaping respiratory care.🔗 Registration coming soon—save your seat.

🧬 EGPA and Hypereosinophilic Syndrome: Why IL-5 Matters

Eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES) are rare eosinophilic disorders associated with multi-organ damage.

At the center of both diseases: activated eosinophils.

Key mechanistic insights:

• Cytotoxic granule protein release → tissue injury
• IL-5 regulates eosinophil maturation, mobilization, and survival
• Tissue eosinophils do not recirculate and persist via local cytokine support
• Activated eosinophils contribute to endothelial dysfunction and thrombotic risk

EGPA phenotype distinction:

🔹 ANCA-positive → vasculitic features
🔹 ANCA-negative → eosinophil-driven tissue infiltration

Mechanism-based therapies targeting IL-5 or its receptor are approved or in development.

🎥 Now available on demand.
For more information, visit:
https://buff.ly/XXPaogs

We are live from !
✔️ Live, in person
✔️ Live webcast available

🔗 https://bit.ly/EGPAHES

Attending in person or virtually? Sign up for a breakfast session on EGPA & HES, featuring expert discussions on pathophysiology, diagnostics, and biological treatments. ✔️ Available live on-site ✔️ Streamed webcast option 🔗 https://bit.ly/EGPAHES

At or joining from afar?
Register for a breakfast symposium on EGPA & HES with expert insights on pathophysiology, diagnosis, and biologic treatment.
✔️ Live, in person
✔️ Live webcast available
🔗 https://bit.ly/EGPAHES

Kick off your morning with CME COMPETE™, an interactive, case-based CME program focused on the
management of nonadvanced systemic mastocytosis (SM).This engaging experience combines expert-led education with friendly competition to help clinicians refine diagnosis, classification, and treatment strategies using real-world scenarios.
Attend in person in Philadelphia or join via live stream.🗓 Saturday, February 28, 2026
⏰ 6:00–8:00 AM ET (in person) | 6:30–8:00 AM ET (live stream)
📍 Philadelphia Marriott Downtown or online🔗 Register now for free access

Kick off your morning with CME COMPETE™, an interactive, case-based CME program focused on the management of nonadvanced systemic mastocytosis (SM).This engaging experience combines expert-led education with friendly competition to help clinicians refine diagnosis, classification, and treatment strategies using real-world scenarios.
Attend in person in Philadelphia or join via live stream.🗓 Saturday, February 28, 2026
⏰ 6:00–8:00 AM ET (in person) | 6:30–8:00 AM ET (live stream)
📍 Philadelphia Marriott Downtown or online🔗 Register now for free access

Early recognition of T1D changes outcomes.

Earn 0.5 CME/CE credits in this interactive activity with Dr. Bithika Thompson covering autoantibody screening, staging, and referral pathways for patients at risk of type 1 diabetes.

Free. Enduring. Online.

Start now:
https://www.exchangecme.com/T1DAct1