UF Innovate Tech Licensing

Research advances in targeted leukemia therapy! 🚨

Current leukemia immunotherapies can struggle to distinguish cancerous cells from healthy tissue, limiting treatment precision and increasing side effects.

Researchers Dr. Christoph Rader and Dr. Matthew G. Cyr from Scripps Research and The Wertheim UF Scripps Institute have developed human antibodies that selectively target Siglec-6, a receptor associated with chronic lymphocytic leukemia (CLL) and other diseases. The platform can be developed into multiple therapeutic formats, including monoclonal antibodies, bispecific antibodies, and antibody-drug conjugates.

By focusing on a more specific disease marker, this approach may enable more selective targeting of leukemia cells while sparing healthy tissue. This University of Florida innovation supports the development of more precise immunotherapies for blood cancers.

🔗 License this tech today: https://ufinnovate.technologypublisher.com/techcase/MP26054

May is National Inventors Month, a time to celebrate the innovators whose ideas improve lives and shape the future. 💡

From breakthrough technologies to startup companies, University of Florida inventors turn research into real-world impact. Their creativity drives progress across healthcare, agriculture, engineering, AI, and more.

Ready to confidentially disclose your innovation? We're here to help!
Start here 🔗: https://innovate.research.ufl.edu/tech-licensing/innovators/innovator-portal/

🥽 Cybersickness, including symptoms like nausea, fatigue, and eyestrain, remains a major barrier to the widespread adoption of in education, training, entertainment, and healthcare.

Researchers at UF BME, led by Dr. Daniel Ferris, developed a brain-informed system for tracking brain activity and mitigating cybersickness during immersive virtual reality experiences.

Using high-density electroencephalography (EEG), the platform detects neural patterns linked to sensory conflict and dynamically applies brief visual adjustments to help users stay comfortable without disrupting immersion.

This University of Florida technology applies brief visual adjustments to help improve synchronization between visual and vestibular brain regions, helping reduce the onset and severity of cybersickness symptoms.

This tech is now available for licensing!

🔗 Learn more and license here: https://ufinnovate.technologypublisher.com/techcase/MP26034

How reliable are tools designed to detect AI-generated research?

Patrick Traynor, Ph.D., professor and interim chair of the UF Department of Computer & Information Science & Engineering, and collaborators evaluated commercially available AI text detectors and found major inconsistencies in performance. 🚨

Presented at the 2026 IEEE Symposium on Security and Privacy, the University of Florida study showed that even minor changes to vocabulary and writing style could significantly reduce detection accuracy, raising concerns about the use of these tools in academic and other high-stakes settings. The researchers concluded that current AI-generated text detectors are not yet reliable or robust enough to accurately determine whether text was written by AI.

Read more: https://innovate.research.ufl.edu/researchers-probe-efficacy-of-ai-detection-tools/

Delivering drugs to the brain remains one of the biggest challenges in treating neurological diseases. Fewer than 2% of approved therapeutics effectively reach the central nervous system (CNS).🧠

Researchers from UF BME have developed a fungal–nanoparticle drug delivery platform that helps transport therapeutics across the blood-brain barrier. Using an avirulent strain of Cryptococcus neoformans, the system carries drug-loaded nanoparticles to the brain and spinal cord through immune-cell–mediated transport.

The platform aims to improve treatment delivery for conditions such as ALS and glioblastoma while reducing off-target effects and the need for invasive CNS delivery methods. This University of Florida innovation could support more effective therapies for a wide range of neurological disorders.

This tech is available now for licensing!
🔗: https://ufinnovate.technologypublisher.com/techcase/MP26035

Clean hydrogen production is essential for reducing industrial emissions, but current methods often rely on energy-intensive oxygen separation, external heating, and processes that generate significant CO₂ emissions. 🌎

Researchers at the Mechanical & Aerospace Engineering Department at UF, led by Dr. Jonathan Scheffe and Dr. Kathryn Trimm, have developed an integrated chemical-looping system that converts methane into high-purity hydrogen, carbon monoxide, and nitrogen streams.

The process uses coupled redox cycles to eliminate the need for external oxygen separation and heating. By integrating endothermic and exothermic reaction steps, the technology improves thermal efficiency through internal heat recovery while minimizing direct CO₂ formation.

This University of Florida innovation supports cleaner energy solutions and more efficient industrial processes. Learn more about this tech below!

🔗: https://ufinnovate.technologypublisher.com/techcase/MP26033

Terrestrial snails can damage crops, and current control methods often rely on chemicals or inefficient bait traps. This creates a need for a more effective, low-cost, and reusable solution.

Researchers at the University of Florida, including Dr. Xavier Martini, Kathi Malfa, and Dr. Isaac Esquivel from the UF Entomology & Nematology Department, have developed a vertical snail trap that uses visual and behavioral cues to improve capture rates. 🐌

Unlike traditional traps that rely primarily on bait alone, this approach combines both visual attraction and behavioral tendencies to significantly increase effectiveness. The design features a dark, tree-like PVC structure that mimics natural vertical stems. The trap also includes a funnel cap and a removable bait drawer for easy cleaning and quick bait replacement, making it reusable, practical, and low-maintenance.

This system offers a more efficient and sustainable approach to agricultural pest management. Learn more and license this tech today! ⬇️

🔗: https://ufinnovate.technologypublisher.com/techcase/MP26044

Long-duration space missions depend on storing cryogenic fuel, but fuel loss remains a major challenge. Even small amounts of heat can trigger boil-off, causing liquid fuel to evaporate into gas, reducing efficiency and increasing mission costs. 🚀

Researchers at the Mechanical & Aerospace Engineering Department at UF, led by Dr. Jacob Chung and Jimmy Almacddissi, have developed a Parylene-C coating for cryogenic storage tanks. The coating creates a smoother, low-thermal surface that makes boiling less likely to start and helps reduce fuel loss.

By minimizing boil-off, the technology helps retain more usable fuel during extended missions. This University of Florida innovation supports more efficient space travel, enabling longer missions and improved performance for future exploration beyond Earth orbit.

Learn more and license this tech 🔗: https://ufinnovate.technologypublisher.com/techcase/MP26031

A major gap in solar and optoelectronic research is understanding how charge carriers behave under real operating conditions.

Researchers at the University of Florida’s Department of Chemistry, led by Dr. Wei Wei and Yue Hu, developed a DNA-based molecular ruler that quantitatively measures the steady-state energy and population distribution of plasmon-generated hot carriers in metal nanocrystals. This is the first benchmark reference for quantifying the steady-state energy and population distributions of photo-generated charge carriers under continuous optical excitation.

Because performance depends on carriers at specific energy levels, not just total output, this parameter is critical for real-world systems.By making it measurable, this UF Research innovation enables more accurate evaluation and optimization of materials used in photocatalysis, solar cells, and sensors.

💡 This tech is available for licensing: https://ufinnovate.technologypublisher.com/techcase/MP25093