02/12/2025
Episode 943: Portal Vein Thrombosis
Contributor: Travis Barlock, MD
Educational Pearls:
1️⃣What is Portal Vein Thrombosis?
-The formation of a blood clot within the portal vein, which carries blood from the gastrointestinal tract, pancreas, and spleen to the liver
-Not only can this cause problems downstream in the liver, but the backup of venous blood can cause ischemia in the bowels
2️⃣How does it present?
-Similar to acute mesenteric ischemia: Sudden onset of abdominal pain, nausea, vomiting, and fever
3️⃣How is it diagnosed?
-Abdominal CT or MRI with contrast
4️⃣What causes it?
-Cirrhosis
-Coagulopathy (Factor V Leiden mutation, Prothrombin gene mutation, Antiphospholipid syndrome, Protein C, protein S, antithrombin III deficiency, etc.)
-Oral Contraceptive Pills (OCPs)
-Cancer such as hepatocellular carcinoma
5️⃣How is it treated?
-Aggressive fluid resuscitation
-Antibiotics. Be sure to cover enteric gram-negative bacteria and anaerobes
-Heparin, same dosing as a bolus for a DVT
-Endovascular treatment, such as a thrombectomy with IR
-Surgical evaluation if there has been tissue death in the mesentery
Summarized by Jeffrey Olson MS3 | Edited by Jorge Chalit, OMS3
Image from:
Gameiro AF, Robalo Nunes A, Guerra P, Mateus E, Fernandes F. Portal Vein Thrombosis Secondary to Occult Polycythemia Vera. Eur J Case Rep Intern Med. 2020 Nov 2;7(12):002003. doi: 10.12890/2020_002003. PMID: 33457359; PMCID: PMC7806286.