AI Biosciences, Inc.

A publication with Dr. Robert Meagher's group at the Sandia Nation Laboratories. We thank Dr. Taylor Moehling for developing a sensitive colorimetric Chagas disease detection assay with us.

Development of a Colorimetric Loop-Mediated Isothermal Amplification Assay for the Detection of Trypanosoma cruzi in Low-Resource Settings Chagas disease is an inflammatory parasitic infection caused by Trypanosoma cruzi (T. cruzi). Early diagnosis is crucial in guiding treatment and slowing disease progression; however, current diagnostic methods have insufficient detection limits and often require skilled technicians. Molecular tests...

Our company developed the PrintrLab for nucleic acid extraction with added capabilities to perform isothermal amplification reactions such as LAMP and RPA.

Evaluation and validation of a PrintrLab-based LAMP assay to identify Trypanosoma cruzi in newborns in Bolivia: a proof-of-concept study The PrintrLab-LAMP yielded a higher sensitivity than microscopy-based analysis. Considering the simpler use and expected lower cost of LAMP compared with PCR, our findings encourage its evaluation in a larger study over a wider geographical area.

A publication with a team led by scientists at NASA JPL.

Frontiers | Assessing microbial diversity in Yellowstone National Park hot springs using a field deployable automated nucleic acid extraction system Microbial diversity estimation involves extracting nucleic acids from intricate sample matrices. Preparing nucleic acid samples is time-consuming, necessitat...

"The µTitan system is a novel automated DNA extraction system, created by Season Wong Ph.D., co-founder of AI Biosciences and initially tested by JPL and UVM in remote field locations as proof of principle."

https://www.med.uvm.edu/com/news/2023/11/06/uvm_s_novel_dna_extraction_technology_goes_to_space

Our new publication with a group at the University of Alabama at Birmingham.

PrintrLab incubator: A portable and low-cost CO2 incubator based on an open-source 3D printer architecture Growth in open-source hardware designs combined with the decreasing cost of high-quality 3D printers have supported a resurgence of in-house custom lab equipment development. Herein, we describe a low-cost (< $400), open-source CO2 incubator. The system is comprised of a Raspberry Pi computer connec...

Our new paper with The Medical College of Wisconsin: A Rapid SARS-CoV-2 RT-PCR Assay for Low Resource Settings

A Rapid SARS-CoV-2 RT-PCR Assay for Low Resource Settings Quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay is the gold standard recommended to test for acute SARS-CoV-2 infection. However, it generally requires expensive equipment such as RNA isolation instruments and real-time PCR thermal cyclers. As a pandemic, COVID-19 has sp...

Our new paper. A great team effort with folks at NASA-JPL, NASA-Ames, University of Vermont, Montana State University, and IRPI.

Validating an Automated Nucleic Acid Extraction Device for Omics in Space Using Whole Cell Microbial Reference Standards NASA has made great strides in the past five years to develop a suite of instruments for the International Space Station in order to perform molecular biology in space. However, a key piece of equipment that has been lacking is an instrument that can extract nucleic acids from an array of complex hu...

https://youtu.be/OyaXBrttBFQ

A Bridge Above: 20 Years of the International Space Station "What if we built a bridge, between and above all nations, to jointly discover the galaxy's great unknowns?" Join us this fall as we prepare to celebrate the...

A Rapid COVID-19 RT-PCR Detection Assay for Low Resource Settings Quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay is the gold standard recommended to test for acute SARS-CoV-2 infection. It has been used by the Centers for Disease Control and Prevention (CDC) and several other companies in their Emergency Use Authorization (EUA) assays...

The Potential Use of Unprocessed Sample for RT-qPCR Detection of COVID-19 without an RNA Extraction Step Quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay is the gold standard recommended to test for acute SARS-CoV-2 infection.[1][1]–[4][2] It has been used by the Centers for Disease Control and Prevention (CDC) and several other companies in their Emergency Use Authorizati...

We had an exhibit at the inaugural 2019 Space Health Innovation Conference in San Francisco, co-Hosted by UCSF and TRISH (11/02/2019). We thank the organizer for providing us a prime location for our table/display.

3-D Printable Tools May Help Study Astronaut Health New technology could cut months off the time it takes to study molecular biology on the International Space Station.