Faculty/Postdoc/PhD Positions & Science

Tumor organoids as a revolutionary platform for advancing cancer nanomedicine – Research

Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translational gap created by conventional preclinical models. These models often fail to recapitulate patient-specific tumor heterogeneity and the complex dynamics of the tumor microenvironment. This review posits that emerging tumor organoid platforms, particularly tumor organoid-on-a-chip systems, represent a transformative solution....

Tumor organoids as a revolutionary platform for advancing cancer nanomedicine – Research Nanomedicine has revolutionized oncology through targeted drug delivery and theranostic applications. However, its clinical translation remains a formidable challenge, primarily due to the translat…

Biomimetic Shell-Core Nanoparticles Loaded With Apatinib for Dual Starvation and Chemodynamic Combination Therapy of Lung Cancer – Research

Tumor cells rely heavily on vascular nutrient supply and glucose metabolism to sustain proliferation, while maintaining redox homeostasis through reprogrammed antioxidant systems, making it difficult for single starvation therapy or chemodynamic therapy (CDT) alone to achieve durable and effective antitumor efficacy. To address these limitations, we developed a cancer cell membrane (CMC)-coated core-shell biomimetic nanoplatform, termed ACuA@CMC, for synergistically enhanced dual-starvation therapy and CDT....

Biomimetic Shell-Core Nanoparticles Loaded With Apatinib for Dual Starvation and Chemodynamic Combination Therapy of Lung Cancer – Research Tumor cells rely heavily on vascular nutrient supply and glucose metabolism to sustain proliferation, while maintaining redox homeostasis through reprogrammed antioxidant systems, making it difficu…

RNA structure programs endogenous ADAR for precise and efficient editing – Research

LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts. Read more about this post... Credits: Source Disclaimer

RNA structure programs endogenous ADAR for precise and efficient editing – Research LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts. Read more about this …

PhD Candidate (m/f/d) job with Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. – (Jobs)

The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry, computer science, medicine, pharmacology, and physics....

PhD Candidate (m/f/d) job with Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. – (Jobs) The Leibniz-Institut für Analytische Wissenschaften – ISAS – e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, …

PhD Candidate (m/f/d) job with Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. – (Jobs)

The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagnosis, and therapy of diseases like cardiovascular diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry, computer science, medicine, pharmacology, and physics....

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Law School Faculty Assistant – Open Positions

University of San Diego (San Diego, CA) Read more about his post... Credits: Source Disclaimer

Law School Faculty Assistant – Open Positions University of San Diego (San Diego, CA) Read more about his post… Credits: Source Disclaimer

Dietary fat alters goblet cell function and microbial bile acid metabolism to promote intestinal lipid absorption in mice – Microbiology Research

Chew, N. W. S. et al. The global burden of metabolic disease: data from 2000 to 2019. Cell Metab. 35, 414–428.e3 (2023). Article CAS PubMed Google Scholar Liu, T.-C. et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host Microbe 29, 988–1001.e6 (2021). Article CAS PubMed PubMed Central…...

Dietary fat alters goblet cell function and microbial bile acid metabolism to promote intestinal lipid absorption in mice – Microbiology Research Chew, N. W. S. et al. The global burden of metabolic disease: data from 2000 to 2019. Cell Metab. 35, 414–428.e3 (2023).Article CAS PubMed Google Scholar Liu, T.-C. et al. Western diet induces …

Prion-based protein self-assembly tunes mutagenesis to enable rapid adaptation – Research

Prion-based protein self-assembly enables reversible switching of genome-maintenance pathways during rapid adaptation and the emergence of drug resistance. Read more about this post... Credits: Source Disclaimer

Prion-based protein self-assembly tunes mutagenesis to enable rapid adaptation – Research Prion-based protein self-assembly enables reversible switching of genome-maintenance pathways during rapid adaptation and the emergence of drug resistance. Read more about this post… Credits:…

Hydroxyl-Terminated Polyethylene Glycol Evades Human Pre-existing Anti-polyethylene Glycol Antibodies – Research

Polyethylene glycol (PEG) has been extensively utilized in food, cosmetics, and pharmaceutical fields, especially in the realm of nanomedicines, where it serves as a pivotal excipient to prolong the nanoparticles' circulation half-life. Contrary to its historical perception as being nonimmunogenic, pre-existing anti-PEG antibodies have been widely detected in human even in individuals without prior exposure to PEGylated therapeutics and are associated with clinically relevant adverse effects of PEGylated nanomedicines including infusion reactions and hypersensitive reactions....

Hydroxyl-Terminated Polyethylene Glycol Evades Human Pre-existing Anti-polyethylene Glycol Antibodies – Research Polyethylene glycol (PEG) has been extensively utilized in food, cosmetics, and pharmaceutical fields, especially in the realm of nanomedicines, where it serves as a pivotal excipient to prolong th…