Panacea Sciences

Estrogen protects the kidneys – research from Dresden and Heidelberg proves the relevance of gender-specific medicine for understanding disease and therapy.

One of the main causes of acute kidney damage is ferroptosis, also known as “biological rust.” This process causes the loss of nephrons, which are the functional units of the kidney. In the study, the research team led by Prof. Andreas Linkermann, who works at the Medical Clinic III (MK III) at Dresden University Hospital (UKD) and is director of the V. Medical Clinic at Mannheim University Medical Center, and Prof. Stefan Bornstein, director of MK III at UKD, demonstrated that the female reproductive hormone estrogen protects the kidneys in many ways against damage caused by ferroptosis.

https://www.eurekalert.org/news-releases/1094688

Nature study: Estrogen protects the kidneys – research from Dresden and Heidelberg proves the relevance of gender-specific medicine for understanding disease and therapy The number of people suffering from kidney disease is rising worldwide. According to estimates by the World Health Organization (WHO), kidney disease will be one of the five leading causes of death by 2050. Kidney disease often goes undetected for a long time, meaning that damage is already at a cri...

In the hormone clinic, we found that counting calories is less effective for weight loss than intermittent fasting and counting carbs.

Intermittent fasting also helps restore hormonal balance for women on advanced HRT protocols.

Here is an excellent article about it.

The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months: A Randomized Clinical Trial: Annals of Internal Medicine: Vol 0, No 0 Background: Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidel...

Hormone therapy (HT) can help women manage menopause symptoms into their 80s, and the reasons are varied, according to a retrospective analysis being presented at the annual meeting of The Menopause Society.

"It's important to know that this is a preselected group of women who had no contraindications to continuing their hormone therapy," senior author Wendy Wolfman, MD, director of the Menopause Clinic and The Premature Ovarian Insufficiency Clinic at Mount Sinai Hospital in Toronto, Ontario, Canada, said in an interview. "They had the initiation of hormone therapy closer to menopause and carried on their hormones. We followed them for a long time and basically saw no real concerns about taking the hormones and the patients did very well. It's important to emphasize this was not the new initiation of hormone therapy in elderly women."

Advanced Hormone Balancing Clinic



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Scans comparing women at different menopausal stages revealed progressively higher ER density in several estrogen-regulated brain networks in the postmenopausal and perimenopausal groups compared to premenopausal controls.

The researchers interpret this as a compensatory response to waning levels of available estrogen— as estrogen levels drop during the menopause transition, the cells express additional receptors to sop up as much estrogen as possible.

Scans Show Brain's Estrogen Activity Changes During Menopause The transition to menopause is marked by a progressively higher density of estrogen receptors (ER) on brain cells, a measure that remains elevated in women up to their mid-60s, according to a new brain imaging study led by researchers at Weill Cornell Medicine.

Women benefit from estrogen no matter how old they are. According to Menopause the journal of the Menopause Society.

Compared with never use or discontinuation of menopausal hormone therapy after age 65 years, the use of estrogen monotherapy beyond age 65 years was associated with significant risk reductions in mortality (19% or adjusted hazards ratio, 0.81; 95% CI, 0.79-0.82), breast cancer (16%), lung cancer (13%), colorectal cancer (12%), congestive heart failure (CHF) (5%), venous thromboembolism (3%), atrial fibrillation (4%), acute myocardial infarction (11%), and dementia (2%). For the use of estrogen and progestogen combo-therapy, both E+ progestin and E+ progesterone were associated with increased risk of breast cancer by 10%-19%, but such risk can be mitigated using low dose of transdermal or vaginal E+ progestin. Moreover, E+ progestin exhibited significant risk reductions in endometrial cancer (45% or adjusted hazards ratio, 0.55; 95% CI, 0.50-0.60), ovarian cancer (21%), ischemic heart disease (5%), CHF (5%), and venous thromboembolism (5%), whereas E+ progesterone exhibited risk reduction only in CHF (4%).

Use of menopausal hormone therapy beyond age 65 years and... : Menopause en from 2007-2020 and Cox regression analyses adjusted for time-varying characteristics of the women, we examined the effects of different preparations of menopausal hormone therapy on all-cause mortality, five cancers, six cardiovascular diseases, and dementia. Results Compared with never use or di...

The constant ebb and flow of hormones that guide the menstrual cycle don't just affect reproductive anatomy. They also reshape the brain, and a study has given us insight into how this happens.

Led by neuroscientists Elizabeth Rizor and Viktoriya Babenko of the University of California Santa Barbara, a team of researchers tracked 30 women who menstruate over their cycles, documenting in detail the structural changes that take place in the brain as hormonal profiles fluctuate.

The results, which are yet to be peer-reviewed but can be found on preprint server bioRxiv, suggest that structural changes in the brain during menstruation may not be limited to those regions associated with the menstrual cycle.

For The First Time, Scientists Showed Structural, Brain-Wide Changes During Menstruation The constant ebb and flow of hormones that guide the menstrual cycle don't just affect reproductive anatomy.

5600 women with hypoestrogenism who were prescribed vaginal estrogen for the prevention of recurrent urinary tract infections, the frequency of urinary tract infection decreased by more than 50% in the following year. Baseline urinary tract infection frequency, increasing age, urinary incontinence or retention, and diabetes were associated with an increased risk of postprescription urinary tract infection. The paradoxical finding that women with moderate and high medication adherence experienced the lowest-magnitude reduction in urinary tract infection frequency may represent unobserved selection or unmeasured confounding.

Efficacy of vaginal estrogen for recurrent urinary tract infection prevention in hypoestrogenic women - PubMed In this retrospective review of 5600 women with hypoestrogenism who were prescribed vaginal estrogen for the prevention of recurrent urinary tract infections, the frequency of urinary tract infection decreased by more than 50% in the following year. Baseline urinary tract infection frequency, increa...

Women who reported to have s*x weekly during the study period were 28% less likely to experience menopause than women who had s*x less than monthly.

Sexual frequency is associated with age of natural menopause: results from the Study of Women's Health Across the Nation | Royal Society Open Science It is often observed that married women have a later age of natural menopause (ANM) than unmarried women; however, the reason for this association is unknown. We test an original hypothesis that s*xual frequency acts as a bio-behavioural mediator between ...

Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. Herein, we revealed the role of gut microbiota in the development of IBD and related anxiety-like behavior in ERβ-deficient mice.

Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior - Microbiome Background Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. Herein, we revealed the role of gut microbiota in the development...