MIT Center for Gynepathology Research

MIT Center for Gynepathology Research The page for the MIT Center for Gynepathology Research To donate, please visit: https://giving.mit.edu/search/node/gynepathology.

The Center for Gynepathology Research (CGR, or The Center) launched in 2009 with the goal of bringing new frontiers of engineering to understanding the basic biology, physiology, and pathophysiology of the female reproductive tract. The Center sought to answer questions like, “We’re giving endometriosis patients drugs, but do we really know their level of pain, and exactly what’s causing it?” and

basic science questions like, “How do endometriosis / adenomyosis lesions cause inflammation?” and “How do drugs affect endometriosis lesions?”
Since CGR’s founding, through collaboration among engineers, biologists, and clinicians, it has focused on both basic and translational research to make sense of three things related to endometriosis:
• the wide range of ways endometriosis / adenomyosis afflicts patients,
• the diversity of patient responses to available therapies for these common and morbid diseases, and
• the failure of many patients to respond to any existing therapies. CGR investigators dive into these questions from the level of basic science – growing lesions from patient-derived tissues – all the way to the clinic – piloting new technologies to monitor patient pain and discomfort non-invasively at home. The Center fosters liaisons with industry, and its research (https://cgr.mit.edu/research/) leverages all facets of engineering, with an emphasis on “biological engineering”—fusing approaches from tissue engineering and systems biology to understand disease etiology and progression. The Center hosts seminars and workshops on topics related to gynepathologies and provides infrastructure for experimental work with primary cells and tissues from patients, sharing new reagents they develop with investigators around the world. This fosters development of new gynepathology-related projects at MIT and in the local Cambridge/Boston community. The Center also has an active teaching outreach program at MIT, involving many undergraduate students in research and providing clinical exposure for MIT pre-medical students. Please see the CGR People section (https://cgr.mit.edu/people/) for lists of current lab students, postdocs, staff, clinical fellows, collaborators, and advisors. If you would like to financially support the mission of the MIT Center for Gynepathology Research, we will ensure your funds are well spent to transform the understanding and treatment of diseases affecting women’s reproductive health by exploiting the latest developments in tissue engineering, cell, and molecular biology research.

https://cgr.mit.edu/2022/03/21/wbur-segment-discusses-life-with-endometriosis-and-need-for-research/A recent segment on ...
03/21/2022

https://cgr.mit.edu/2022/03/21/wbur-segment-discusses-life-with-endometriosis-and-need-for-research/

A recent segment on WBUR’s Radio Boston, called “Two women share what it’s like living with endometriosis,” opens with Boston University student Yaël Krinsky and her father Alvin describing Yaël’s yearslong journey with endometriosis and the toll it has taken on her and their family.

The segment continues with host Tiziana Dearing interviewing CGR Director Linda Griffith about research she and others are doing to learn more and treat this disease. Dr. Griffith explains how millions of people live with the severe pain of endometriosis, but most wait years for a diagnosis. She shares personal stories, including how she (like Krinsky) lived with endometriosis, undiagnosed then inaccurately treated, for years. Dr. Griffith tells listeners why that happens, and the status of research that is helping improve the odds for better diagnosis and treatments of endometriosis in the future.
Listen Here: https://www.wbur.org/radioboston/2022/03/17/living-with-endometriosis
This segment aired on March 17, 2022.

EndometriosisNews & Events A recent segment on WBUR’s Radio Boston, called “Two women share what it’s like living with endometriosis,” opens with Boston University student Yaël Krinsky and her father Alvin describing Yaël’s yearslong journey with endometriosis and the toll it has taken o...

S**X and Immunity Event Raises Crucial Questions for SocietyFollow the link for a recap of our terrific S**X and Immunit...
03/09/2022

S**X and Immunity Event Raises Crucial Questions for Society

Follow the link for a recap of our terrific S**X and Immunity inaugural event at MIT. Experts discussed important questions,
such as “Why are females more likely to survive COVID-19 but at greater risk of developing chronic disease?” and “Historically, why have women and nonbinary people typically been excluded from clinical trials?” and lots more.

News & Events Why are females more likely to survive COVID-19 but at greater risk of developing chronic disease? Historically, why have women and nonbinary people typically been excluded from clinical trials? How do we understand how s*x differences affect everyone? What is the interplay between s*x...

Unexplainable podcast discusses “the mysteries of endometriosis”The August 18, 2021, episode of Vox Media’s Unexplainabl...
08/18/2021

Unexplainable podcast discusses “the mysteries of endometriosis”

The August 18, 2021, episode of Vox Media’s Unexplainable podcast is called “The Mystery of Endometriosis” and features the voices of 14 people discussing their experience with the disease. They share their earliest memories of the condition, the difficulties they had being diagnosed, their frustration when they realized that there was no cure (and, for some, no good treatment options), and the need for more research and funding.
CGR Director Linda Griffith is one of the voices in the podcast. The second half of the episode features a spotlight on Dr. Griffith’s work and the importance of having someone like her – with both personal and academic experience with the disease – in a position to research it. It cites her work to change the definition of endometriosis from “benign” to “common and morbid” as just one example of the ways she can use her breadth of experience to affect change.
Listen Here [link to https://www.vox.com/unexplainable] or wherever you get your podcasts.

Unexplainable is a science podcast from Vox and Vox Media Podcast Network about everything we don’t know. Host Noam Hassenfeld is joined by an array of experts and Vox reporters each week to look at the most fascinating unanswered questions in science and the mind-bending ways scientists are tryin...

Register for "The Science of Endometriosis" Virtual Event, July 11 Please join MIT's Center for Gynepathology Research (...
06/21/2021

Register for "The Science of Endometriosis" Virtual Event, July 11

Please join MIT's Center for Gynepathology Research (CGR) on Sunday, July 11, 2021, 4 to 5 p.m. (ET), to kick off the virtual series, “The Science of Endometriosis.” MIT’s Linda Griffith and Michigan State University’s Stacey Missmer will lead a lively discussion titled Endometriosis 101 – Clinical Studies. They'll answer questions including, "Why aren’t there more clinical studies, and why don’t we know more about endometriosis?" They’ll also answer selected questions sent by registered attendees.
Details and registration here:
https://lnkd.in/d-iiayD

EndometriosisNews & Events Please join us on Sunday, July 11, 2021, from 4 to 5 p.m. (ET), as we kick off the virtual series, “The Science of Endometriosis.” MIT’s Linda Griffith and Michigan State University’s Stacey Missmer will lead a lively discussion titled Endometriosis 101 – Clinica...

“Griffith’s research and inventions have the potential to improve women’s health dramatically. The problem for women is ...
06/18/2021

“Griffith’s research and inventions have the potential to improve women’s health dramatically. The problem for women is that she stands out for another reason: She’s female. In 2020, only 12.8% of U.S. inventors receiving patents were women, and historically male researchers have ignored conditions like endometriosis.”

Boosting the number of female inventors isn't just a matter of fairness. Inventions by men are more likely to ignore women's needs.

"I've had a fabulous career in science. It's an amazing career for women." Prof Linda Griffith to Terry Gross, host of N...
05/14/2021

"I've had a fabulous career in science. It's an amazing career for women." Prof Linda Griffith to Terry Gross, host of NPR's Fresh Air.

Find the full interview wherever you get your podcasts, or by clicking here: http://ow.ly/ruTR50EMgGy

"So I'm a member of several Facebook patient-support groups, and I monitor what people are posting about. So there are c...
05/13/2021

"So I'm a member of several Facebook patient-support groups, and I monitor what people are posting about. So there are comorbidities that you get with endometriosis, and one of them is called Ehlers-Danlos syndrome...
So we're actually studying this in the lab, and it's because people were posting on Facebook groups. And I didn't know what it was, and their posts led me to look into it." Professor Linda Griffith on NPR's Fresh Air.
For full interview, click below or here:

MIT bioengineer Linda Griffith spent years in debilitating pain before she was diagnosed with a condition often neglected in research. Her focus on the basic biology could lead to better treatments.

NPR’s “Fresh Air” show features interview with CGR Director Linda GriffithThe May 13, 2021 edition of NPR’s Fresh Air sh...
05/13/2021

NPR’s “Fresh Air” show features interview with CGR Director Linda Griffith

The May 13, 2021 edition of NPR’s Fresh Air show features Terry Gross interviewing CGR Director Linda Griffith. They discuss endometriosis, the important work CGR researchers are doing to understand and address this widespread disease, and how it could hold clues to tissue regeneration.

Listen here (also available as a podcast):

MIT bioengineer Linda Griffith spent years in debilitating pain before she was diagnosed with a condition often neglected in research. Her focus on the basic biology could lead to better treatments.

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