The Picower Institute for Learning and Memory

The Picower Institute for Learning and Memory The Picower Institute for Learning and Memory at MIT focuses the talents of a diverse array of brain Professor Li-Huei Tsai has served as director since 2009.

The Picower Institute is an independent research entity within MIT’s School of Science, dedicated to understanding the biology and neuroscience behind learning and memory and related functions such as perception and consciousness. Researchers investigate the basic science of the brain and explore how their findings may produce new treatments and methods of diagnosis. Faculty members hold academic

appointments in Brain and Cognitive Sciences, Biology, Chemical Engineering, IMES, and the Broad Institute. The Institute offers exciting research opportunities for scholars at all levels, from undergraduates to post-docs. In 1994, MIT first established a world-class, multidisciplinary neuroscience research center, initially with a grant from the Sherman Fairchild Foundation and then continued with long-term support from the RIKEN Brain Science Institute and the National Institute of Mental Health. In 2002, under the directorship of Dr. Susumu Tonegawa, we received an extraordinary gift from the Picower Foundation, the Center was renamed as the Picower Institute for Learning and Memory. We now have 14 faculty members and as many research groups, with a total staff of nearly 200 researchers and supporting personnel.

New theory! The brain's ability to generate cognition and consciousness arises from analog computations carried out by e...
08/19/2026

New theory! The brain's ability to generate cognition and consciousness arises from analog computations carried out by electrical waves. Review in JNeurosci led by Earl K. Miller: https://picower.mit.edu/news/cognition-and-consciousness-arise-analog-computations-says-new-theory
Study with co-authors Scott Brincat and Jefferson Roy: https://www.jneurosci.org/content/46/33/e0711262026

The brain's ability to generate quick, nimble volitional thought—and a unified awareness of thought and experience—arises from analog computations carried out by electrical waves, MIT neuroscientists argue in a new review

Flexible brain circuits can switch between different tasks. Neuroscientists have discovered circuits in the prefrontal c...
08/17/2026

Flexible brain circuits can switch between different tasks. Neuroscientists have discovered circuits in the prefrontal cortex that can be repurposed to store different types of information. News: https://picower.mit.edu/news/flexible-brain-circuits-can-switch-between-different-tasks
Study led by Yuma Osako in the lab of Mriganka Sur: https://www.nature.com/articles/s41593-026-02410-0

Neuroscientists have discovered circuits in the prefrontal cortex that can be repurposed to store different types of information.

With Mass. Women’s Health Award, team will study how Alzheimer’s risk varies with hormone replacement https://picower.mi...
07/29/2026

With Mass. Women’s Health Award, team will study how Alzheimer’s risk varies with hormone replacement https://picower.mit.edu/news/mass-womens-health-award-team-will-study-how-alzheimers-risk-varies-hormone-replacement Massachusetts Life Sciences Center

Observations conflict about whether hormone replacement therapy increases or decreases Alzheimer’s likelihood for women. With a new award from the Massachusetts Life Sciences Center, MIT researchers will investigate the underlying molecular mechanisms aff

06/22/2026

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