W. Harry Feinstone Department of Molecular Microbiology and Immunology

W. Harry Feinstone Department of Molecular Microbiology and Immunology The official student-run page for students, alumni, faculty, and staff of the MMI department at Johns Hopkins Bloomberg School. Welcome all!

We are pleased to release this page as a forum to share departmental news and announcements, present research articles you found interesting, and to network with colleagues new and old.

07/31/2026

Anti-Spike monoclonal antibodies (mAbs) progressively lost efficacy during the COVID-19 pandemic due to the emergence and predominance of resistant SARS-CoV-2 variants. By contrast, high-titre COVID-19 convalescent plasma (CCP) collected from vaccinated donors recently recovered from infection provi...

07/28/2026

Persistent infection with high-risk human papillomavirus (HPV), particularly HPV16, is a major driver of HPV-associated cancers; however, strategies for treating established HPV-induced tumors remain scarce. Here, we developed a DNA-based vaccine linking the SARS-CoV-2 spike (S) protein with an HPV1...

07/28/2026

Despite a decade of indoor residual spraying, malaria remains holoendemic in Nchelenge District in northern Zambia. This study examined the hypothesis that the intransigence of malaria in Nchelenge District is due in part to early evening and outdoor foraging of local anopheline species. Three repli...

07/24/2026

We investigated how inflammatory fibroblasts (IFs) contribute to acute viral myocarditis, a dangerous inflammatory heart disease often caused by infections like coxsackievirus B3 (CVB3). Using CCL2-mCherry reporter mice, we tracked IF kinetics during CVB3 infection and discovered that their activity...

07/24/2026

SARS-CoV-2 continues to circulate with the emergence of variants that evade existing immunity. However, all strains rely on conserved host factors for entry, making them attractive targets for host-directed antivirals. SARS-CoV-2 engages the ACE2 receptor and can enter cells through two alternative....

07/18/2026

Primary idiopathic hyperhidrosis (PIH) is a poorly understood disorder characterized by excessive sweating. We identify a genetically defined subset of PIH associated with rare coding changes in voltage-gated Na+ (NaV) channels. Whole-exome sequencing of hereditary PIH families...

07/17/2026

As generative AI becomes a standard fixture in graduate education, the pedagogical challenge has shifted from detection to integration. This article describes a curriculum intervention developed for Anatomy of Scientific Error, a graduate-level course on scientific error analysis in interdisciplinar...

07/17/2026

With this status report, we aim to provide a timely snapshot of the protein engineering field as a broad and rapidly advancing discipline that integrates computational, molecular biology, structure-guided, evolutionary, and synthetic approaches to create new and improved proteins with tailored struc...

07/14/2026

Human fungal pathogens cause a significant public health burden. While no reliable surveilence data are available, estimations suggest that 1 billion infections and over 2 million deaths are attributable to fungal infections annually worldwide. This drove the World Health Organization to generate a....

07/12/2026

Intact HIV-1 proviruses become progressively enriched in transcriptionally repressive genomic regions during long-term antiretroviral therapy (ART) and in elite controllers, raising questions about their capacity for reactivation in vivo. We used an antigen-restricted quantitative viral outgrowth as...

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