10/09/2026
For some people with type 1 diabetes, even careful insulin therapy cannot prevent dangerous fluctuations in blood glucose. Islet transplantation can help by replacing the insulin-producing cells destroyed by the disease, but clinicians currently have limited tools to determine whether a patient’s immune system is rejecting the transplanted cells.
Researchers in the lab of Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering at the University of Michigan, in collaboration with Esma Yolcu, Professor of Molecular Microbiology & Immunology at the University of Missouri, are investigating whether implantable biomaterial-based immunological niches can detect early immune changes associated with islet transplant rejection and characterize the underlying immune mechanisms.
Read more: https://bme.umich.edu/2026/10/09/synthetic-immunological-niches-could-offer-an-earlier-warning-of-islet-transplant-rejection/