Epilepsy Center

A new paper from Epilepsy Center has been published in *Experimental Neurology* highlighting the role of the extracellular matrix, particularly Collagen VI, in the regulation of network excitability in epilepsy. You can access the paper here: https://doi.org/10.1016/j.expneurol.2024.114911.

Key Highlights of the Paper:

Role of Collagen VI: The study demonstrates how Collagen VI modulates synaptic transmission, contributing to the regulation of neuronal excitability, which is crucial in understanding epilepsy mechanisms.

Potential Therapeutic Target: Findings suggest that targeting Collagen VI or its pathways could offer new avenues for developing treatments to control or prevent seizures.

Potential Biomarker: The research also highlights the potential of Collagen VI as a biomarker for epilepsy, which could be used to predict or monitor the disease's progression and response to treatment.

Comprehensive Analysis: The research combines molecular, cellular, and network-level analyses, providing a holistic view of how Collagen VI impacts brain excitability.

This research project has a long and storied history, beginning around 2008-2009 with my PhD student, Litsa Nikitidou. The project was later taken over by my postdoc, Alessandra Cifra, and subsequently by another postdoc, Tania Ramos. Over the years, many collaborators contributed significantly to this work, including groups funded by the EU Commission under the EPITARGET project at various stages. The final phase of the project was brought to completion by my PhD student, Esbjörn Melin.

Given its lengthy timeline, this project might just set a Guinness World Record for duration in neuroscience research! Joking aside, I want to extend my heartfelt thanks to everyone who contributed to this publication over the years. Your dedication and collaborative spirit have been essential to bringing this important work to fruition.

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Corona: Remote PhD thesis defense at Epilepsy Center, Lund University.
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Dissertation behind closed doors – Epilepsy Center Today, Friday March 27, Esbjörn Melin defended his thesis, the last milestone of his research studies. Advancing gene therapy for epilepsy - Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor.

New paper published in Journal of NeuroScience, 2019
Long-term, targeted delivery of GDNF from encapsulated cells is neuroprotective and reduces seizures in the pilocarpine model of epilepsy

Gene Therapy targets Epilepsy - Nature Outlook, 2018
Repairs for a runaway brain - Gene therapy could damp down epilepsy seizures in people for whom current drugs are ineffective

New paper from Experimental Epilepsy Group:
Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizuresFredrik Berglind, My Andersson & Merab Kokaia. Scientific Reports | (2018) 8:5669 | DOI:10.1038/s41598-018-23659-x

Dynamic interaction of local and... (PDF Download Available) Full-Text Paper (PDF): Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizures

Simple blood test could reveal epilepsy risk http://bit.ly/2F3gD8a

Simple blood test could reveal epilepsy risk A finger-prick blood test to diagnose epilepsy could be available within five years, according to scientists who are using tell-tale molecules called biomarkers to overcome current diagnostic problems and guide treatment.

CURE | Epilepsy Awareness Month 2015 November is Epilepsy Awareness Month, and our commitment is unrelenting. With just three dollars, you hold the power to Fund A CURE for epilepsy. Create your personalized CURE profile picture and share with your network.

http://www.med.lu.se/nyheter/131209_epilepsi

Stort EU-anslag till ny epilepsiforskning | Medicinska fakulteten, Lunds universitet Faculty of Medicine, Lund University, provides Education and research in the area of health

http://www.sydsvenskan.se/lund/epilepsiforskare-far-miljonanslag/

Epilepsiforskare får miljonanslag 60000 personer i Sverige och mer än 50 miljoner människor i hela världen lider av epilepsi. Dagens läkemedel ger ofta biverkningar eller har ingen effekt...

Epilepsy Center a part of Epilepsy Center @ Lund University Hospital