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Intersting case !! Middle age female , presented with jaundice, gall stones , splenomegaly and anemia . She has no hitory of blood transfusion or hospital admission. Has family history of gall stones , and her daughter had anemia and splenomegaly . CBC hb: 8.1 TWBC 8.8 plt 247 MCV 75 , has high total bilirubin level mainly direct, viral screening is negative , blood film and full CBC below , what is the most likely diagnosis??

Target cells , what is the diseases associated with target cells ??

Normal CBC values,
From: Color atlas of clinical hematology
Victor hoffbrand

Clinical case : A 68-year-old man is referred for evaluation of increased
bruising, primarily on his forearms, for the last 3 months. He restores old cars for a hobby and believes that trauma associated with this work may have caused his bruises, although he cannot recall specific instances during which he injured himself. He denies epistaxis, melena, or other evidence of systemic bleeding. He is in otherwise good health other than mild hypertension treated with an angiotensin converting enzyme inhibitor; he does not take other prescription medications but takes fish oil and vitamin C supplements. On physical examination, he looks
well but several 2.0 cm bruises are noted on the distal upperextremities and back of the hands. Complete blood count reveals a hemoglobin of 12.8 gm/dL, white blood cell (WBC) count of 6.9 × 109/L, and platelet count of 22 × 109/L. What is the possible diagnosis??

Clinical case :
Patient is a healthy 48-year-old female of African descent who is
referred to you for evaluation of refractory microcytic anemia.
She has been treated with oral iron formulations many times
throughout her life. Hemoglobin values have always ranged
from 10-11 g/dL with a mean corpuscular volume (MCV) ranging from 69-74 fL. She has no other prior medical history. Her
examination is entirely unremarkable. Peripheral blood smear is
significant for microcytosis, mild anisopoikilocytosis, and a small
number of target cells. The hemoglobin concentration is 10 g/dL with an MCV of 71 fL and mean corpuscular hemoglobin (MCH)
of 23 pg. Additional laboratory studies include a transferrin saturation of 32% and ferritin 490 ng/mL. Hemoglobin electrophoresis reveals hemoglobin A 98% and hemoglobin A2 1.8%.
What is the possible diagnosis??

What is this RBCs inclusion ? And its clinical significance ?

Refresh your memory !!
What are the causes of leucopenia??

55 years old female ,TWBCs 74,000 ,
Hb 9 g/dl ,MCV 82, Plt 299,000
Blood film and full CBC below. What is the possible diagnosis ??

New case ,CBC : TWBCs : 51,000 Hb: 8.6
Plt 189,000 .Blood film and full CBC below ,what are your thoughts ??

What is the clinical significance of these cells ??

MCQs:Which of the following is a major risk factor for venous thrombosis?
a. Smoking
b. High cholesterol
c. Hypertension
d. Diabetes mellitus
e. Cancer

Hematological changes in visceral leishmaniasis:
Patients ,from endemic areas, present with fever , wieght loss, features of anemia , lymph node enlargment, cough, epistaxis
Lab tests : shows anemia ,thrombocytopenia ,and leucopenia.
Serological testing can be done RK39.
The gold standard for diagnosis is Bone marrow or splenic aspirates whish show large numbers of parasitized macrophages (LD bodies)
Treatment : liposomal Amphotericin b