Bioinformatics in Sudan

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Immunoinformatics Predication and in silico Modeling of Epitope-Based Peptide Vaccine Against virulent Newcastle Disease Viruses

This is a paper we published recently.
Abstract:
Newcastle disease virus (NDV) is negative sense single stranded RNA belongs to the Avulavirus genus of the Paramyxoviridae family which can be transmitted by inhalation or ingestion. Birds infected shed these viruses in f***s as well as respiratory secretions. The aim of this study is to analyze fusion (F) protein of all virulent Newcastle strains reported in NCBI database using in silico approaches to select all possible epitopes that can be used as a therapeutic peptide vaccine. A total of 56 virulent NDV fusion protein variants retrieved from NCBI database. The conserved regions were introduced into IEDB analysis resource to predict B and T cell epitopes, as well as predicting the binding affinity of the conserved epitopes with BF2 21:01, from the predominantly expressed chicken MHC I molecule. Epitopes with high scores in both B and T cell epitopes predicting tools were suggested. Peptide vaccine against virulent NDV is strongly supersedes the conventional vaccines, as it designed to cover variant virulent mutated strains, which will reduce the recurrent outbreaks and their huge accompanied economical loss to a minimum.

full published paper can be seen through: http://pubs.sciepub.com/ajidm/4/3/3/

ملخص الدراسة:
العينة تحت الدراسة كانت كافة عينات البروتين التي تم وصفها كخطيرة وممرضة جدا في دراسات سابقة, تمت دراسة كافة هذه البروتينات التي تم تحليلها في مناطق مختلفة في العالم لنتمكن بعدها من دراسة المناطق الاقل طفرة والمشتركة في كافة العينات تحت الدراسة قدر الامكان, ليتم تحليل هذه المناطق ودراسة امكانية تكوينها للقاح يهدف خصيصا للوقاية من الفايروسات الاكثر خطورة من نيوكاسل فايرس والتي بالتالي هي مرتبطة بتاثير اكثر ضراوة اقتصاديا وصحيا.

الباحثين في الورقة وكما يظهر في الورقة المنشورة هم:
Marwan Mustafa Badawi, Afra AbdElhamid Fadl Alla, Salma Sleak Alam, Wafa Aljack Mohamed, Duaa Adil Nasr-Eldin Osman, Samar Ali Abd Alrazig Ali, Entissar Mohamed Elhassan Ahmed, Abdah AbdElmonim Adam, Ranya Omar Abdullah and Mohamed Ahmed Salih.

شكرا لكل من ساهم ودعم ووجه. نتوجه في الخطوة القادمة في هذا البحث وغيره لبدء مرحلة التحقق الفعلي من خلال التجارب المعملية من فعالية استخدام هذا اللقاح وغيره وسلامتها من الناحية العضوية للاستخدام.
كل من يرغب في الاستفسار أو المشاركة والتعاون في مشاريع بحثية مختلفة سنكون أكثر من سعداء للتواصل.

Zika virus vaccine prediction authors contribution in vaccine and vaccination conference in Italy.
http://vaccines.global-summit.com/europe/eposter-presentation.php

Poster Competition | Vaccines Research Conferences | Health Conferences | Vaccines R & D... Vaccines poster competition, Vaccines PPT, Vaccines Immunology PDF, Active immunization, Specific Immunization, Nonspecific immunization, Adopted Immunotherapy, Passive immunization

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Now... DNA extraction of lymphoma tissues. By researchers in African City of technology.