The Cayo Santiago Biological Field Station (CSBFS) is managed by the Caribbean Primate Research Center under the administration of the University of Puerto Rico. The goal of the CSBFS is to investigate behavioral and physiological aspects of development, aging, comparative cognition, reproduction, and coping mechanisms for stress. The longitudinal approach to studying behavior on the rhesus macaque population of Cayo Santiago maximizes the use of the primate resources by combining a) field observations of social and cognitive behaviors; b) state-of-the-art techniques for the generation of physiological, immunological, neurological, and neuroendocrinological data; and c) genealogical and genetic information. The animal care program of the CPRC is in full compliance with the directives established by the Animal Welfare Act (AWA). It is also monitored by the Institutional Animal Care and Use Committee (IACUC) of the UPR-MSC and the Animal Plant Health Inspection Services (APHIS) of the USDA. The CPRC is fully accredited by the American Association for Accreditation of Laboratory Animal Care International (AAALAC). The CPRC is supported by The Office of Research Infrastructure Programs (ORIP) of the National Institute of Health (NIH) through Grant Number 2 P40 OD012217, and the UPR.