The Biologically Active Metallopeptides Research Group

Strona główna
Polska
Wroclaw
The Biologically Active Metallopeptides Research Group

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We are interested in the coordination chemistry, structure and thermodynamics of metal-peptide complexes, with special focus on the interactions of antimicrobial peptides and metallophores with Zn(II), Cu(II) or Ni(II).

22/09/2026

LL-37 has been studied for decades as an important human antimicrobial peptide, but what do we actually know about its interactions with metal ions?

In our latest Dalton Transactions paper, we take a closer look at Cu(II) and Zn(II) binding by LL-37, its shorter DF-12 fragment, and the all-D analogue df-12.

Does peptide shortening change metal coordination? Does inversion of stereochemistry matter? And can metal binding influence antimicrobial activity?

Interestingly, the answers are not the same for Cu(II) and Zn(II).

This study is also a great example of how much can come from combining expertise across different research groups. It was carried out in collaboration with Michał Jewgiński and Rafał Latajka from the Department of Bioorganic Chemistry - WUST, Tomasz Janek from the Biotechnologii i Mikrobiologii Żywności Uniwersytet Przyrodniczy we Wrocławiu, and Denise Bellotti from the Department of Chemical, Pharmaceutical and Agricultural Sciences, Università degli Studi di Ferrara.

Authors: Klaudia Szarszoń, Marta Luszawska, Michał Jewgiński, Tomasz Janek, Rafał Latajka, Denise Bellotti and Asia Wątły.

Take a look at the full story in Dalton Transactions:
DOI: 10.1039/D6DT01638C

21/09/2026

Sharing our passion for science at the Lower Silesian Science Festival (Dolnośląski Festiwal Nauki)!

On 15-16 September, we had the pleasure of taking part in the Lower Silesian Science Festival, where we shared our knowledge and enthusiasm for science with younger participants.

During the festival, dr Joanna Wątły, and her PhD students Klaudia Szarszoń, and Anna Ślusarczyk led two hands-on workshops:

🧬DNA Mission – Discover the Secrets Hidden in Fruits
🧪Chemistry in a New Light – Discover What’s Hidden in Food

Through experiments and interactive activities, we explored fascinating aspects of DNA, chemistry and the science behind everyday food. Most importantly, we wanted to show that science is not only about textbooks and formulas - it can be exciting, surprising and fun to discover!

It was a great opportunity to introduce around 100 children to the world of science, encourage their curiosity, and show them that even the most ordinary things around us can hide extraordinary scientific secrets. We hope we inspired some future scientists along the way.

Dolnośląski Festiwal Nauki
Wydział Chemii Uniwersytetu Wrocławskiego
Uniwersytet Wrocławski

07/09/2026

Another conference, another BAM success, another Best Scientific Poster Award! 🔬🏆

From September 1–4, 2026, our team had the pleasure of taking part in 3rd International Conference On Metal-Binding Peptides (MBP2026) in Dresden, Germany, where we had the opportunity to present our latest research and exchange ideas with researchers from around the world.

We are especially proud that so many members of our team were actively involved in the scientific programme:

🎤 Asia and Aleksandra gave invited lectures
🎤 Kinga, Klaudia, Gabriela and Ania presented their work in oral sessions
📊 Wojtek presented his research in a poster session
🏆 A special congratulations to Kuba, who received the Best Scientific Poster Award! 🎉
🤝 And Magda was the co-chair of the conference, helping make MBP2026 happen!

It was a great opportunity to share our results, discuss new ideas and, of course, spend some time together outside the lab. 🧪🤝

A huge thank you to the MBP2026 organizers for a great conference and to everyone we had the pleasure of meeting and talking to!

See you at the next one! 👋

Wydział Chemii Uniwersytetu Wrocławskiego
Uniwersytet Wrocławski

13/07/2026

Mirror, mirror on the wall, who is the most antimicrobial of us all? 🪞🦠

Congratulations to our PhD student Ania Ślusarczyk on the publication of her first first-author research article in RSC Advances!

This work explores rational strategies for modifying mucin beyond conventional proteolytic approaches, contributing to a better understanding of its properties and expanding its potential for future biomedical and materials science applications.

We warmly congratulate all co-authors on this achievement and thank everyone whose expertise, collaboration, and dedication made this work possible, with special thanks to Dr. Joanna Watly for her supervision and invaluable guidance throughout this work.

We also gratefully acknowledge the financial support of Narodowe Centrum Nauki that enabled this research.

You can read the paper here: https://pubs.rsc.org/ra/article/doi/10.1039/d6ra02768g/1276858/Beyond-proteolysis-rational-modification-of-mucin

12/07/2026

The Wrocław delegation has arrived in sunny Tuscany! ☀️🇮🇹

During the Chemistry Towards Biology 12 (CTB12) conference, held in Siena on July 6-9, we had the opportunity to present the results of our research and attend inspiring lectures delivered by outstanding scientists from across Europe.

Magda gave a plenary lecture, while Asia, Aleksandra, Kinga, and Klaudia presented their research in oral presentations.

But that's not all! Three of our PhD students - Kuba, Ania, and Gabriela also actively contributed to the scientific program by delivering short oral presentations and presenting their research during the poster sessions.

We would like to sincerely thank the conference organizers, Daniela Valensin and A***n Kola, for their warm welcome to such a large delegation from Wrocław and for creating an inspiring atmosphere that fostered scientific exchange and collaboration.

We are returning home with fresh ideas, new connections, and a renewed sense of motivation. We are already looking forward to the next edition of CTB!

Uniwersytet Wrocławski
Wydział Chemii Uniwersytetu Wrocławskiego

06/07/2026

We’re happy to celebrate another successful thesis defense season in our group! 🎉

🎓 Congratulations to our MSc graduates: Paulina Sobol, Piotr Smolec (supervised by Dr. Aleksandra Hecel), Martyna Kniaś, and Jan Kachnowicz (supervised by Dr. Joanna Wątły) on defending their excellent Master's theses. Your hard work has truly paid off, and we’re proud of what you’ve achieved! 👏

We’re especially excited that all of our MSc graduates are planning to continue their academic journey at the Doctoral School. Wishing you every success as you take this next step - we’ll be cheering you on! 🚀

🎓 Congratulations as well to our BSc graduates: Aleksandra Kononowicz (supervised by Dr. Joanna Wątły) and Zuzanna Czerbniak (supervised by Dr. Aleksandra Hecel), who successfully defended their outstanding Bachelor's theses. Great job! 🌟

A big thank you to our wonderful supervisors, Dr. Joanna Wątły and Dr. Aleksandra Hecel, for their constant support, guidance, and commitment ✨

01/07/2026

📢 Shine on you crazy clavanin C! 🧬✨

We are excited to share that last week, our latest article was published in ACS Inorganic Chemistry!

In this work, we redesign the antimicrobial peptide clavanin C using stereochemical modifications to create more stable metallopeptidomimetics while preserving their metal-binding properties and biological activity. We show that D-amino acid substitution and a retro-inverso strategy can significantly improve resistance to proteolytic degradation, while maintaining strong antimicrobial activity, including potent effects against methicillin-resistant Staphylococcus aureus (MRSA).

🔗 Read the full Open Access article here:
https://pubs.acs.org/doi/10.1021/acs.inorgchem.6c02172

Congratulations to all co-authors and many thanks to everyone who contributed to this work! 🎉 Kuba Gawłowski, our dear first author and devoted Pink Floyd fan - huge special congratulations to you!!!

24/06/2026

We are thrilled to share that our PhD students Kuba and Klaudia represented the Biologically Active Metallopeptides Group at the International Symposium on the Thermodynamics of Metal Complexes (ISMEC) in beautiful Udine, Italy! 🇮🇹
Klaudia delivered an oral presentation on how stereochemical substitution of two amino acids in an antimicrobial peptide affects its thermodynamics, structure, and biological activity - a fascinating insight into the fine-tuning of peptidomimetic design. Kuba presented a poster on the impact of retro-inverso modification on the coordination behavior, structural characteristics, and biological properties of clavanin C.
And we have even more reason to celebrate - Klaudia was honored with a Special Mention of the S. Sammartano Prize by the ISMEC Scientific Committee!
🏆🎉We couldn’t be prouder of you both! This recognition is a testament to the outstanding science happening in our group. Congratulations, Klaudia and Kuba! 👏

20/06/2026

We are delighted to announce that our BSc student Aleksandra Kononowicz (supervisor: dr Joanna Wątły) received the award for the most interesting presentation on this year's WrocChem 2026 edition, hosted by the Faculty of Chemistry at the University of Wrocław.

What makes this achievement even more remarkable is that the award went to a bachelor's student competing alongside researchers at various stages of their scientific careers.

Our group was proudly represented by five members:

🧪PhD student Gabriela Potoczniak and Wojciech Lizak,

🧪MSc student Ewelina Smaczna and Zuzanna Durska,

🧪BSc student Aleksandra Kononowicz.

Congratulations to Aleksandra on this outstanding success! We would also like to thank all our participants for their excellent presentations and for representing our team so well. We are incredibly proud of you all! 🎉

01/06/2026

Congratulations to Martyna Kniaś (2nd-year Medical Chemistry student) on receiving the Student Award for the Best Presentation at the National Conference Chemistry–Business–Environment (ChemBiŚ) in Gdańsk! 👏🤩

During the conference, Martyna presented the results of her master's research project conducted under the supervision of Joanna Wątły and Anna Ślusarczyk.

We are delighted by this achievement and wish Martyna continued success in her scientific career! ✨

We would also like to thank the Organizing Committee for creating an inspiring scientific forum and for recognizing the achievements of young researchers❤️!

Gratulacje dla Martyna Kniaś (II rok Chemia Medyczna), która zdobyła Nagrodę Studencką za najlepsze wystąpienie zaprezentowane podczas Ogólnopolska Konferencja Chemia-Biznes-Środowisko ChemBiŚ w Gdańsku 👏🤩Pani Martyna podczas konferencji przedstawiła wyniki uzyskane w ramach pracy magisterskiej realizowanej pod czujnym okiem Asia Wątły i Ania Ślusarczyk

Ogromnie cieszy nas to osiągnięcie i życzymy Martynie kolejnych sukcesów na ścieżce naukowej! ✨

Serdecznie dziękujemy również Komitetowi Organizacyjnemu za stworzenie inspirującej przestrzeni do wymiany wiedzy oraz za docenianie osiągnięć młodych naukowców❤️!

Wydział Chemii Uniwersytetu Wrocławskiego ma świetnych studentów :)

Adres

Joliot-Curie 14
Wroclaw
50-383

Strona Internetowa

https://metalamp.wixsite.com/home

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