Centrum Nowych Technologii Uniwersytetu Warszawskiego

🔸 The Centre of New Technologies of the University of Warsaw seeks to establish new, exceptional research groups capable of reinforcing existing expertise or pioneering new directions. We are hiring FIVE new group leaders in biology, chemistry, physics, medicine, archeology and other exact, natural and medical sciences at every level (professor / associate professor / assistant professor).

We offer freedom to lead cutting-edge research in a multinational environment with access to advanced infrastructure and efficient administration.

Interested? See cent.uw.edu.pl/job-offers or contact us at [email protected].

Deadline: March 31, 2026

🔹 The Centre of New Technologies, University of Warsaw invites to a seminar by:

prof. Love Dalén, Centre for Palaeogenetics, Department of Zoology, Stockholm University

Title: Deep-time genomes shed light on mammalian evolution at million-year timescales
Date: Mon Mar 16th, 2026
Time: 12:00 (Central European Time)
Host: prof. Mateusz Baca
The seminar will be held in the 00.142 auditorium, Banacha 2c

Join Zoom Meeting:
https://uw-edu-pl.zoom.us/j/94755910172?pwd=Dudpxb6e4xFdzWsP7T4XrhzlpvXwyt.1
Meeting ID: 947 5591 0172
Passcode: 125371

🔸 Abstract:

In recent years, the temporal limits of ancient DNA recovery have been extended into the Early Pleistocene, enabling genomic analyses across timescales spanning several hundred thousand years. These deep-time datasets provide unprecedented opportunities to investigate macroevolutionary processes in real-time, including speciation, extinction, and long-term adaptation. At the Centre for Palaeogenetics in Stockholm, our recent and ongoing work on Middle and Early Pleistocene genomes has revealed previously unrecognized evolutionary lineages, refined hypotheses regarding species origins, and improved resolution of the timing and rate of adaptive evolution. In this presentation, I will present several case studies on different mammalian species, ranging in size from mammoths to small rodents.

🔹 Zapraszamy 18 kwietnia na Dzień Otwarty na Uniwersytecie Warszawskim!

🇬🇧⬇️ Zapraszamy 18 kwietnia na Dzień Otwarty na Uniwersytecie Warszawskim! To najlepsza okazja, aby zapoznać się z naszą ofertą edukacyjną, zobaczyć kampus, a także porozmawiać z wykładowcami i studentami UW!

💙 W czasie Dnia Otwartego na kampusie głównym UW będą na Was czekać przedstawiciele wszystkich naszych wydziałów. Dowiecie się więcej o programach studiów, zasadach rekrutacji na poszczególne kierunki, czy dodatkowych możliwościach oferowanych przez Uniwersytet Warszawski.

Dzień Otwarty UW:
🗓️ 18 kwietnia 2026
🕙 10:00-16:00
🏛️ Kampus główny, ul. Krakowskie Przedmieście 26/28

Przyjdź i dowiedz się, w jaki sposób dołączyć do najlepszej uczelni w Polsce!

Do zobaczenia!

🇬🇧 Join us on April 18 for Open Day at the University of Warsaw! It's the best opportunity to learn about our educational offerings, see the campus, and talk to UW lecturers and students!

💙 During the Open Day, representatives of all our faculties will be waiting for you at the main campus of the University of Warsaw. You will learn more about study programs, admission rules for individual fields of study, and additional opportunities offered by the University of Warsaw.

University of Warsaw Open Day:
🗓️ April 18, 2026
🕙 10:00 a.m. to 4:00 p.m.
🏛️ Main campus, 26/28 Krakowskie Przedmieście Street

Come and find out how to join the best university in Poland!

See you there!

🔹 Zapraszamy do wysłuchania rozmowy z prof. Jackiem Jemielitym w podkaście UW "muwi się"

https://www.uw.edu.pl/prof-jacek-jemielity-w-podkascie-muwi-sie/

Prof. Jacek Jemielity w podkaście „mUWi się” – Centrum Nowych Technologii to niezależna jednostka badawcza na Uniwersytecie Warszawskim. Naszym głównym zadaniem jest prowadzenie badań naukowych na jak najwyższym poziomie. Równie istotne jest to, by ich znaczenie było widoczne dla społeczeństwa – by pokazywać, że są to działani...

🔹 The Centre of New Technologies, University of Warsaw invites to a seminar by:

prof. Chia-en A Chang

Department of Chemistry, University of California, Riverside

Title: Beyond AlphaFold3: From Physical Chemistry Principles to MachineLearned Physics in Molecular Design
Date: Wed Mar 11th, 2026
Time: 11:00 (Central European Time)
Host: prof. Joanna Trylska
The seminar will be held in the 00.142 auditorium, Banacha 2c

🔸 Abstract:

The presentation will discuss our recent advances in protein variants and cyclic-peptide design in the AI era. While powerful tools such as AlphaFold3 and ProteinMPNN are widely used, what can we do when these data-driven AI methods based on statistical correlations fail? Here we will introduce 1) using residue correlation networks to design high-affinity protein-based binders; 2) teaching AI to learn physics to understand molecular motions and assist cyclic-peptide design. Using all-atom molecular dynamics (MD) simulations, we identify the essential network of residue interactions and dihedral angle correlations critical in protein–protein recognition and guide residue substitution to enhance protein-protein binding. Using ubiquitin (Ub), a central player in multiple cellular functions, and MERS coronaviral papain-like protease (PLpro), an antiviral drug target, our designed ubiquitin variant (UbV) hosting 3 mutated residues achieved a ~3,500-fold increase in functional inhibition relative to wild-type Ub, demonstrating the effectiveness of this physical-chemistry-based approach to design high-affinity protein binders for cell biology research and future therapeutics [1]. We will then introduce our Internal Coordinate Net (ICoN) [2], an autoencoder-based deep learning model that utilizes atomistic bond-angle-torsion coordinates as features and force-field based lost function to learn the physical principles of conformational changes from MD simulation data and to sample novel conformations in the latent space. The talk will highlight how coordinated torsion rotations drive conformational transition pathways in macro-cyclic peptides -- systems with highly concerted atomic motions and complex energy landscapes that challenge traditional conformational sampling and design strategies. We will show how ICoN improves accuracy, interpretability, and computational efficiency of deep learning models to bring scientific insights and assist macrocycle design.

References:

[1] Hung, T. I., Hsieh, Y-J., Lu, W-L., Wu, K-P., and Chang, C-E. A., What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks. J. of Molecular Biology , 435, 168337, 2023.

[2] Ruzmetov T, Hung T. I., Jonnalagedda S. P., Chen S. H., Fasihianifard P., Guo Z., Bhanu B., Chang C-E. A., Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning. Journal of Chemical Information and Modeling, 65(5), 2487–2502, 2025

🔸 Marcin Magnus z grantem NCN SONATA BIS.

Narodowe Centrum Nauki (NCN) ogłosiło laureatów najnowszej edycji grantów NCN SONATA BIS, przyznawanych młodym naukowcom w celu utworzenia własnych grup badawczych. Z radością informujemy, że jeden z grantów otrzymał Marcin Magnus, który będzie kierownikiem projektu „Wykorzystanie uczenia głębokiego do zrozumienia interakcji RNA z małymi cząsteczkami” w Centrum Nowych Technologii Uniwersytetu Warszawskiego. Marcin Magnus kończy obecnie staż podoktorski na Uniwersytecie Harvarda i wkrótce dołączy do Centrum Nowych Technologii jako kierownik Laboratorium Projektowania i Terapii RNA.

Celem Marcina jest zrozumienie ewolucji i roli RNA oraz RNP w systemach biologicznych przy użyciu metod obliczeniowych (uczenie maszynowe, dynamika molekularna, przewidywanie struktury) i eksperymentalnych (genetyka drożdży, biologia molekularna) oraz skodyfikowanie tej wiedzy w predykcyjnych modelach obliczeniowych, które można zastosować w przyszłych terapiach opartych na RNA.

🔹 The Centre of New Technologies, University of Warsaw invites to a seminar by:

prof. Róża Szweda, Adam Mickiewicz University

Title: Programming synthetic polymers with biological precision through sequence control
Date: Fri Mar 6th, 2026
Time: 12:00 (Central European Time)
Host: prof. Jacek Jemielity
The seminar will be held in the 00.142 auditorium, Banacha 2c

🔸 Abstract:

Nature programs the function of biomacromolecules through sequence, arranging monomers with precision to create proteins and nucleic acids capable of folding, recognition, catalysis, and other sophisticated functions. Translating this molecular “language” into synthetic polymers opens largely unexplored opportunities to create materials that combine the programmability of biology with the robustness and versatility of man-made polymers.

In this lecture, I will present our recent advances in the design and synthesis of sequence- and stereochemically defined abiotic polymers that exhibit programmable, protein-mimicking behaviour beyond physiological constraints. By controlling both the order and chirality of monomer units in synthetic polyurethanes, we demonstrate how subtle sequence variations govern chain dynamics, induce defined folding motifs such as helices and sheets, and direct supramolecular organisation in non-biological media.

This structural precision translates into emergent functions, including tunable molecular recognition, catalytic activity, and information storage. Our work demonstrates how entirely synthetic backbones can be programmed to achieve receptor- and enzyme-like properties, opening a pathway toward artificial proteins and establishing a new paradigm for functional materials at the interface of chemistry and biology.

🔸 Przyjdź sprawdzić, jak „gotuje się” odkrycia!

Przepis na idealny DOKO 2026?

✔ 1 szczypta ciekawości
✔ 2 łyżki eksperymentów
✔ garść matematycznych zagadek
✔ odrobina chemicznej reakcji
✔ i solidna porcja pasji badaczy

Wymieszać na Kampusie Ochota. Podawać 21 marca.

Hasło tegorocznej edycji?
👉 NAUKA OD KUCHNI

Bo najlepsze rzeczy dzieją się tam, gdzie powstają – w laboratoriach, pracowniach i salach wykładowych.

Przyjdź sprawdzić, jak „gotuje się” odkrycia!

www.doko.mimuw.edu.pl

Wydział Medyczny Uniwersytetu Warszawskiego Wydział Biologii UW Wydział Fizyki Uniwersytetu Warszawskiego Wydział Chemii Uniwersytet Warszawski Wydział Geologii UW Wydział Psychologii UW Wydział Matematyki, Informatyki i Mechaniki Uniwersytetu Warszawskiego Centrum Nowych Technologii Uniwersytetu Warszawskiego

🔹🔔 Save the date ❗️ Prof. Bartosz Szyszko, the 2025 laureate of the National Science Centre award will give a seminar next Friday (February 27) at noon at the Centre of New Technologies.

Title: Pyrrole-based macrocycles, mechanically interlocked molecules and cages: dynamics, tautomerism, chirality, and luminescence
Date: Friday, Feb. 27th, 2026
Time: 12:00 (Central European Time)
Host: prof. Bartosz Trzaskowski
The seminar will be held in the 00.142 auditorium of the Centre of New Technologies (Banacha 2C, Warszawa).

🔸 Abstract:

Mechanically interlocked molecules (MIMs) represent a unique class of supramolecular systems characterized by the presence of a mechanical bond, with rotaxanes and catenanes serving as prototypical examples. This talk will focus on two fundamental aspects of mechanically interlocked pyrrole-based MIMs. First, it will explore the use of the diiminopyrrole motif in subcomponent self-assembly, [1-3] to construct molecular knots and links that exhibit intramolecular dynamics facilitated by the fluxionality of coordinated metal centers. Furthermore, the discussion will highlight how the introduction of more complex pyrrole-derived building blocks enables the synthesis of mechanically interlocked porphyrinoids, offering new avenues for functional molecular design. The exploitation of iminopyrrole synthons for building intriguing cage architectures demonstrating unique coordination plasticity and tautomeris will be demonstrated. [4-6]

The second part of the talk will discuss a new class of rotaxanes incorporating dipyrromethane stoppers designed to construct dynamic MIMs. [7] A key focus will be on the discovery and characterization of a new mode of molecular motion, referred to as fluttering, which is reminiscent of butterfly wing flapping. The multimodal motion can be precisely modulated using simple acid-base chemistry, providing a versatile platform for designing stimuli-responsive molecules. The higher-order calix[4]phyrin-based mechanically interlocked molecules will also be discussed, further expanding the structural and functional diversity of these systems. [8] Eventually, it will be demonstrated how the molecular editing of an achiral [2]rotaxane comprising a pyrrole ring allows it to transform into the mechanically planar chiral species. [9]

[1] Matviyishyn, M., Białońska, A., Szyszko, B.¸ Angew. Chem. Int. Ed. 2022, anie.202211671.
[2] Sarwa, A., Białońska, A., Sobieraj, M., Martínez, J. P., Trzaskowski, B., Szyszko, B. Angew. Chem. Int. Ed. 2024, 63, e202316489.
[3] Sarwa, A., Khmara, A., Konieczny, K. A., Kulesza, D., Zych, E., Trzaskowski, B., Szyszko, B.,Angew. Chem. Int. Ed., 2025, e202423962.
[4] Sukiennik, J., Sarwa, A., Perdek, J., Siczek, M., Szyszko, B., 2025, Chem. Eur. J. 2025, DOI:10.1002/chem.202502714.
[5] Sarwa, A. Białońska, A., Garbicz, M., Szyszko, B. Chem. Eur. J. 2023, e202203850.
[6] Trzaskowski, B., Martínez, J., Sarwa, A., Szyszko, B., Goddard III, W. J. Phys. Chem. A 2024, 128,3339-3350.
[7] Grzelczak, R. A., Basak, T., Trzaskowski, B., Kinzhybalo, V., Szyszko, B., Angew. Chem. Int. Ed.2025, e202413579.
[8] Grzelczak, R. A., Perdek, J. P., Siczek, M., Chmielewski, P. J., Szyszko, B. Org. Lett. 2025, 27,6310–6315.
[9] Grzelczak, R. A., Perdek, J. P., Siczek, M., Chmielewski, P. J., Szyszko, B., submitted, 2025

🔸 12 lutego 2026 roku dyrektor CeNT, prof. dr hab. Jacek Jemielity powołał w Centrum Nowych Technologii Uniwersytetu Warszawskiego, Laboratorium Symulacji Materiałów i Procesów. Kierownikiem nowego laboratorium został dr hab. Silvio Osella.

Wykorzystuje on metody chemii obliczeniowej do badania właściwości optoelektronicznych i transportowych materiałów niskowymiarowych, za pomocą wieloskalowego podejścia obliczeniowego.

Gratulujemy i życzymy wielu naukowych sukcesów!