Doctor of Physical Therapy - DPT at Glance

HARMONES

STOP THE SPREAD OF COVID-19

Heart Attack: Warning Signs

5 types of Genes found in Covid-19 virus

TYK2
Creates an enzyme that can lead to inflammation

Is targeted with JAK inhibitors and one already approved for use in humans is baricitinib which treats rheumatoid arthritis

CCR2
Targetable by drugs that are in trials but are not widely used, for psoriasis

Evidence for this gene is not as strong as for other genes in the study, but Dr Baillie says it is still 'compelling'

OAS1
Is a gene that initiates a signal that activates an enzyme which degrades RNA derived from viruses.

Several other coronavirus have a way of preventing this mechanism. No evidence yet for SARS-CoV-2, but it might be a specific feature that does this.

Targettable by a class of drugs called phosphodiesterase 12 inhibitors.

These are not currently in clinical trials but theoretically would enhance antiviral effect of this system.

IFNAR2
This is a core part of signalling that is responsible to the host antiviral response.

Signalling in this pathway is important in the chance of getting sick.

Relevant in fighting the virus directly, much like OAS1. This is more important early in the disease as later in the disease, virus levels drops and the issue comes from the body's immune system attacking itself.

DPP9
Known to play several roles in inflammation but the researchers do not yet know exactly where it fits in to the Covid-19 disease progression.

They are therefore unable to make a direct therapeutic prediction.

It is associated with pulmonary fibrosis and might be associated with 'long covid'.

The genes were identified across the genome, with two on chromosome 19 called TYK2 and DPP9. One, called IFNAR2, is found on chromosome 21.

Oh Allah!!

Please have mercy on all of us. Our neighbouring country our brothers, sisters are in need of Your mercy. The entire world needs Your mercy.

Deliver us from this evil (Covid-19).

Ameen Suma Ameen.

Please pray for India, pray for your own, pray for the entire world.

Forgive and forget what has happened in the past, let go of the differences. Just become one world one nation and help one another, be there for each other

Points to remember:
1..)Extraembryonic mesoderm== Epiblast

2...)Extraembryonic coelom==Hypoblast

3...)Intraembryonic coelom== Lateral plate mesoderm