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Regional odontodysplasia

Uncommon developmental abnormality of teeth, usually localized to a certain area of the mouth.
The condition is nonhereditary.
There is no predilection for race, but females are more likely to get regional odontodysplasia.

The enamel, dentin, and pulp of teeth are affected, to the extent that the affected teeth do not develop properly. These teeth are very brittle.
On radiographs the teeth appear more radiolucent than normal, so they are often described as "ghost teeth".

Most cases are considered idiopathic, but some cases are associated with syndromes, growth abnormalities, neural disorders, and vascular malformations. Permanent teeth usually show effects of regional odontodysplasia if the deciduous tooth was affected. Many of these teeth do not erupt, and those that do have an increased risk of caries and periapical inflammation.

Treatment and prognosis

usually based upon keeping these teeth and preserving the alveolus.

For erupted teeth, endodontics is an option if the tooth is devitalized and restorable.
For unerupted teeth, function can be restored with a removable partial denture until all major growth has been completed and a final restoration can be placed.
They cant be brought out by orthodontic means .too and mostly result in ankylosis .
Via Dr Izhar Ali

OSTEOSARCOMA arising in a 17 year old male patient!

THE RADIOGRAPHIC SIGNS:
1- Widening of the PDL membrane space (Garrington sign)
2- Sun ray appearance
MICROSCOPICALLY:
The lesion shows malignant undifferentiated spindle cells with evidence of cartilage differentiation and MOST IMPORTANTLY OSTEID DEPOSITION . Perivascular arrangment was also evident ( high risk factor for metastasis)
Immunophenotyping :
The lesion was negative for cytokeratn, desmin, myogenin, S100 and LCA
Positive for Vimentin and Osteopontin

OSTEOSARCOMA OF THE GNATHIC BONES DO NOT REQUIRE INDUCTION CHEMOTHERAPY ( as opposed to other osteosarcomas)

Kindly check the description on the pictures
Courtesy of Dr. Youssef el Mansy

Periodontolgy Paper 2021 Supplementry