14/10/2025
"๐๐ฃ๐ฐ ๐ข๐ต ๐ด๐ช๐ฑ๐ฐ๐ฏ ๐ฏ๐ข ๐ฎ๐ข๐บ ๐ฌ๐ข๐ด๐ข๐ฎ๐ข๐ฏ๐จ ๐ญ๐ข๐จ๐ฏ๐ข๐ต? ๐๐ข๐ฌ๐ข ๐ง๐ญ๐ถ ๐ฏ๐ข '๐บ๐ข๐ฏ?"
It is the flu season again mga Mhie-krobiyos! Dahil dito na-late rin kami magpost ng pubmat.๐ญ
For this day's edition of Microbe Monday, meet the cause of viral flu - the ๐๐ฏ๐ง๐ญ๐ถ๐ฆ๐ฏ๐ป๐ข virus. ๐ฆ
As the flu season begins, the ๐๐ฏ๐ง๐ญ๐ถ๐ฆ๐ฏ๐ป๐ข virus once again takes the spotlight as a major cause of respiratory illness worldwide. This virus, belonging to the Orthomyxoviridae family, is an enveloped pathogen with a segmented, single-stranded, negative-sense RNA genome that targets the epithelial cells of the respiratory tract. Infection often presents with symptoms such as fever, cough, sore throat, muscle and joint pain, headache, and fatigue, and in severe cases, it can lead to complications like pneumonia or secondary bacterial infections, particularly in vulnerable populations such as the elderly, children, and those with weakened immune systems.
The Influenza virus carries two key surface glycoproteinsโhemagglutinin (HA) and neuraminidase (NA)โwhich play critical roles in viral attachment, entry, and release. These proteins are also the basis for classifying Influenza A subtypes, such as H1N1 and H3N2, that commonly circulate among humans. Due to its segmented genome, the virus is highly prone to mutation, resulting in genetic changes through antigenic drift and antigenic shift. Antigenic drift leads to minor mutations responsible for seasonal epidemics, while antigenic shift results in major genetic reassortments that can cause global pandemics.
Among its four types, ๐๐ฏ๐ง๐ญ๐ถ๐ฆ๐ฏ๐ป๐ข A and B are the primary causes of human seasonal epidemics, while type C results in mild infections and type D primarily affects cattle. ๐๐ฏ๐ง๐ญ๐ถ๐ฆ๐ฏ๐ป๐ข A viruses are further classified into subtypes based on HA and NA combinations, and Influenza B viruses are divided into two major lineages known as Victoria and Yamagata. Wild aquatic birds serve as the natural reservoir of ๐๐ฏ๐ง๐ญ๐ถ๐ฆ๐ฏ๐ป๐ข A viruses, facilitating interspecies transmission and contributing to their genetic diversity. Because of its capacity for constant change and widespread transmission, the Influenza virus remains a persistent global health concern.
Annual vaccination remains the most effective preventive strategy, with vaccine formulations updated each year to match circulating strains. Alongside immunization, maintaining proper hygiene through regular handwashing, practicing respiratory etiquette, and avoiding close contact with symptomatic individuals are crucial in reducing transmission. As this flu season unfolds, it is vital to stay protected, informed, and proactive in preventing infection. Through awareness, vaccination, and responsible health practices, we can collectively reduce the burden of ๐๐ฏ๐ง๐ญ๐ถ๐ฆ๐ฏ๐ป๐ข and safeguard our communities.
Stay safe in this season of flu mga Mhie-krobiyos!
References:
Centers for Disease Control and Prevention (CDC). (2024). Key facts about influenza (flu). https://www.cdc.gov/flu/
Krammer, F., Smith, G. J. D., Fouchier, R. A. M., Peiris, M., Kedzierska, K., Doherty, P. C., ... & Palese, P. (2018). Influenza. Nature Reviews Disease Primers, 4(1), 3.
Taubenberger, J. K., & Morens, D. M. (2008). The pathology of influenza virus infections. Annual Review of Pathology, 3, 499โ522.
Tong, S., Zhu, X., Li, Y., Shi, M., Zhang, J., Bourgeois, M., ... & Donis, R. O. (2013). New world bats harbor diverse influenza A viruses. PLoS Pathogens, 9(10), e1003657.
Webster, R. G., Bean, W. J., Gorman, O. T., Chambers, T. M., & Kawaoka, Y. (1992). Evolution and ecology of influenza A viruses. Microbiological Reviews, 56(1), 152โ179.
World Health Organization (WHO). (2024). Influenza (Seasonal). https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal)