DermNet

A patchy eruption in pregnancy… What could it be? Find out more in this clinical case carousel or on our DermNet page: https://dermnetnz.org/cases/pregnant-21-year-old-with-patchy-skin-eruption

Chronic hand eczema 🖐 Erythema, scaling, fissuring… and often significant impact on quality of life. When topical steroids aren’t enough (or suitable), newer options are emerging.

Delgocitinib is a topical pan-JAK inhibitor - offering a steroid-free treatment for moderate-to-severe chronic hand eczema.

Read more about delgocitinib here: https://dermnetnz.org/topics/delgocitinib

Pictured from left to right:
- Woolly hair from birth
- Striate keratoderma of the palms
- Marked hyperkeratosis over pressure areas on the feet
- Plantar keratoderma of the soles

This combination is classic for Naxos disease - a rare genetic cardiocutaneous syndrome. 💡 Key clue: Early hair changes + palmoplantar keratoderma should prompt consideration of an underlying cardiac condition (arrhythmogenic cardiomypathy).

Learn more on our website: https://dermnetnz.org/topics/naxos-disease

Bee and wasp stings are common and usually result in mild, localised reactions such as pain, erythema, and swelling.

Read more on our carousel and on our website here: https://dermnetnz.org/topics/bee-and-wasp-stings

Uraemic pruritus (also called chronic kidney disease–associated pruritus) is a persistent itch that occurs in people with advanced kidney disease, particularly those receiving dialysis. The itch can be severe, often worse at night, and commonly affects the back, arms, head, or abdomen, significantly impacting sleep and quality of life.

Read more here: https://dermnetnz.org/topics/uraemic-pruritus

Nemolizumab is a targeted biologic therapy used in dermatology to treat conditions driven by severe itch, particularly moderate-to-severe atopic dermatitis and prurigo nodularis (pictured). It works by blocking the IL-31 receptor, a key pathway involved in chronic itch and skin inflammation, helping reduce pruritus and improve skin symptoms.

Read more here: https://dermnetnz.org/topics/nemolizumab

What can cause a well-demarcated, symmetrical rash over the dorsum of both feet 👣 ? Think beyond infection…

Read more about the case here: https://dermnetnz.org/cases/a-strapping-foot-rash

Bed bugs are small blood-feeding insects that typically bite exposed skin during sleep, often causing itchy red bumps that may appear in clusters or a line- sometimes called the “breakfast, lunch, and dinner” pattern. Interestingly, up to 70% of people may have little or no reaction to the bites, making infestations difficult to recognise.

Read more here: https://dermnetnz.org/topics/bed-bugs

Erythema multiforme is an immune-mediated skin condition characterised by distinctive “target” or bullseye-shaped lesions that often appear on the hands, feet, and limbs. It is usually triggered by infections (most commonly herpes simplex virus) and is typically self-limiting, although some cases may involve mucous membranes.

Read more here: https://dermnetnz.org/topics/erythema-multiforme

Did you know that this condition may sometimes be associated with cystic fibrosis or carriers of the CF gene? Read the full case here: https://dermnetnz.org/cases/swollen-painful-palms-following-water-exposure