13/02/2022
Case Study.
“When I was training as a student in medicine, Scotland had the highest rate of heart disease in the world. Early on the answer for why was, ‘Oh, well, it's because we have such terrible diet, and we eat rubbish food like deep fried Mars bars.’
So, you eat too much saturated fat, the saturated fat gets turned into cholesterol in your bloodstream, and then it’s absorbed into arteries and forms narrowings and thickenings, which all sounds plausible if you don't think about it too hard.
But I also happen to go to France quite a lot, and what I noticed about France was, they eat a lot of saturated fat. They eat more, in fact, than anyone else in Europe, and certainly more than Scotland. So, [this saturated fat] hypothesis certainly didn't work for the French. They have the highest saturated fat intake in Europe and lowest rate of heart disease, and this has been the case for decades.
If you took all the risk factors for France and Scotland [such as smoking, high blood pressure and diabetes], then the French had slightly [higher risk], according to conventional thinking. But, in fact, they had one-fifth [the rate among age-matched men].
So, I thought, this is interesting. It doesn't make much sense according to what we're told. Then while I was in medical school, a tutor in cardiology said ... LDL cannot cross the endothelium. At the time, I didn't know what LDL was, nor did I know what the endothelium was, but it sounded important.
She had been looking at heart disease as a different process for decades ... So, I think that's really where I got started. Once you start questioning what the problem is, you end up questioning more and more and you start thinking, gosh, this is just nonsense, isn't it? This whole hypothesis is just nonsense. So, I started picking it apart.”