IFIND

What is autophagy? (Part 2)

Autophagy is essential for a cell to survive and function.
1. Recycles damaged cell parts into fully functioning cell parts.
2. Gets rid of nonfunctional cell parts that take up space and slow performance.
3. Destroys pathogens in a cell that can damage it, like viruses and bacteria

Autophagy plays an important role when it comes to aging and longevity, too. As a person ages, autophagy decreases, which can lead to a build-up of cellular junk parts and, in turn, cells that aren’t functioning at their best.

Inducing autophagy

You can induce autophagy by stressing your cells to send them into survival mode. You can induce autophagy through:

1. Fasting: Fasting means that you stop eating for a certain amount of time. Fasting deprives your body of nutrients, forcing it to repurpose cell components to function.

2. Calorie restriction: Restricting your calories means decreasing the number of energy units, or calories, your body consumes. Instead of depriving your body of calories completely (as with fasting), you limit them. This forces your cells into autophagy to compensate for the lost nutrients.

3. Switching to a high-fat, low-carb diet: This type of diet, commonly referred to as a keto diet, changes the way your body burns energy, so that instead of burning carbs or sugar for energy, it burns fat instead. This switch can trigger autophagy.

4. Exercise: Exercise stimulates processes that increase the activity of ATGs, such as stressing your skeletal muscles. Exercise can induce autophagy, depending on the type of exercise you’re doing and its intensity.

5. Spermidine. Spermidine tricks the brain into autophagy.

https://my.clevelandclinic.org/health/articles/24058-autophagy #:~:text=You%20can%20induce%20autophagy%20by,repurpose%20cell%20components%20to%20function.

Autophagy (Part I)

Nobel Prize

2016 Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi for discovering the mechanisms for autophagy.

Autophagy, is a process or mechanism in your body that it will eat up the bad cell and regrouping the good cell to achieve homeostasis in your body. So it is like “pacman” in your body eating up yourself but to make you healthier.

It has a broader role in biology including organellar remodeling, protein and organelle quality control, prevention of genotoxic stress, tumor suppression, pathogen elimination, regulation of immunity and inflammation, maternal DNA inheritance, metabolism, and cellular survival. *1

Autophagy is important in maintaining liver homeostasis by eliminating damaged organelles and proteins. Dysfunction of autophagy in liver parenchymal and non-parenchymal cells can lead to various liver diseases including non-alcoholic fatty liver diseases, alcohol associated liver disease, drug-induced liver injury, cholestasis, viral hepatitis and hepatocellular carcinoma. Therefore, targeting autophagy may be a potential strategy for treating these various liver diseases. *2

*1 https://www.pnas.org/doi/10.1073/pnas.1619876114 #:~:text=On%20October%203%2C%202016%2C%20the,in%20a%20simple%20organism—baker%27s
*2 https://pubmed.ncbi.nlm.nih.gov/34120768/

Autophagy inducer

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兔年🐰🐰🐰来咯🧨🧨🧨🧧🧧🧧！

你，妳，都準備好用全新的面孔迎接吗？

Orgderm 补水面膜一盒5片，连续使用5天，不会在🔟公里外都看到你或妳油光满面。Orgderm 补水面膜让我和你👨和妳👩，容光焕发1️整年。

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Thinking of living till old age?

Thinking of living till old age and healthily?

Is that possible?

There is a village two hours outside of Tokyo where people live well into their 90s and, more importantly, have youthful skin and minimal health issues such as diabetes, heart disease, and cancer, even though some of them smoke and are exposed to the sun.

Diseases like cancer, diabetes, and Alzheimer’s are very rare.

The villagers have high hyaluronic acid levels in their bodies.

The name of the village is Yuzurihara, or wrinkle-free village.

Photo credits: https://www.hyaluronic-acid.co.uk/the-story-of-ha/

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Do you have a darker skin tone?

The reason for darker skin is that the melanosomes are spread throughout the epidermis, whereas in fair skin, the melanosomes are not in the upper layers of the epidermis.

The darker skin has a natural skin protection factor about 7.4% of ultraviolet radiation and probably filter twice as much UV radiation as fair-skinned people.

photo credits: https://www.avyaskincare.com/blogs/blog/what-makes-dark-skin-dark-and-light-skin-light

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Smoking?🚬🚬🚬 Good.

Please go ahead if it helps you to

1. Gives you more ideas.....🧠🧠🧠
2. May be more inspiration........✍️✍️✍️
3. Looking macho...😎😎😎
4. Whatever the reason...

just do not drag too hard......🫁 🫁 🫁 jangan tarik kuat sangat....

Take care 😈😈😈

Photo Credits: https://www.sknclinics.co.uk/blog/the-effects-of-smoking-on-your-skin

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Myth or fact? Men have thicker skin compared to women.

Any idea how much is men's skin thicker than women? (Answers in the comment section.)

So now you know what they said about men is ..... 😂😂😂

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