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Low- and High-Density Lipoprotein Cholesterol and Dementia Risk Over 17 Years of Follow-up Among Members of a Large Health Care Plan Background and Objectives The associations of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) with dementia risk in later life may be complex, and few studies have sufficient data to model nonlinearities or adequately adjust for statin use. We evaluated t...

Read this synopsis of the 2023 updated ARDS guidelines from the European Society of Intensive Care Medicine, including the guidelines’ methods, findings, and implications, along with reflections on next steps. https://ja.ma/3NdE565

Continuous administration of meropenem, compared with intermittent administration, does not improve clinically relevant outcomes in critically ill patients with sepsis. https://ja.ma/46aaljl

Should women >75 years old still get screening mammograms? This article sorts through the national and international guidelines and reviews the pros and cons of screening in these patients. https://bit.ly/3WqGcYs

Patient Information: Syphilis This JAMA Patient Page describes syphilis, its signs and symptoms, diagnosis, and treatment.

Age-related macular degeneration affects many individuals older than 55 years, impacting the central vision and leads to issues with reading, driving, and the ability to recognise faces.

A new Review explores treatment options and further opportunities for prevention:
https://hubs.li/Q01Qc1th0

👇 Figure: FAF images of geographic atrophy

A 55-year-old man who had been admitted to the intensive care unit had a sudden-onset vesicular rash appear across his trunk and arms, as shown. He had undergone a small-bowel resection; his post-operative course had been complicated by sepsis, fevers, and respiratory failure. On exam, he was wrapped tightly in blankets. The vesicles did not rupture with light palpation but broke when more pressure was applied. What is the diagnosis? https://nej.md/3MkMLZm

Haemochromatosis is an inherited disorder defined by an excess of body iron. It is often overdiagnoses in patients without iron overload, but underdiagnosed in many other patients. With potentially fatal complications, early detection via genetic testing is crucial.

A new Seminar explores current treatments, diagnosis tools and future directions: https://hubs.li/Q01P6_Sg0

👇 Figure: Underlying pathophysiology of haemochromatosis in four stage.

In this study, among patients with trauma at risk of massive transfusion, there was no significant reduction of 24-hour blood product consumption after administration of 4F-PCC, but thromboembolic events were more common. https://ja.ma/3H8Syy3

Extracorporeal cardiopulmonary resuscitation may increase survival in patients with refractory cardiac arrest, who typically have mortality rates higher than 90%. https://ja.ma/3Ve07JB