Psiconeurobiologia - Roberto Gradini

An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation A pathogenic CDC42 M45L variant strengthens binding to pyrin B30.2, triggering inflammasome activation and autoinflammatory disease.

Comparative insights into insula structure and function - Nature Neuroscience Charbonneau et al. compare how the insula is structured and functions in humans, monkeys and rodents, revealing similarities and differences across species that are likely to impact the translation of animal research to humans.

Obstructive Hypertrophic Cardiomyopathy | NEJM A 31-year-old man was evaluated for an abnormal ECG. Echocardiography revealed marked ventricular hypertrophy. Subsequent imaging (shown in a video) showed near-complete apposition of the ventricul...

Type 1 Autoimmune Pancreatitis | NEJM A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated.

Syncope | NEJM Syncope is a common clinical problem caused by transient cerebral hypoperfusion and encompasses reflex, orthostatic, and cardiac mechanisms. Accurate diagnosis relies on careful history taking and ...

1. Department of Experimental Medicine, Sapienza University, Rome 🇮🇹 20’s -
-Memento: Rise and fall of memory formation, storage and retrieval. 2. -Space and Time disorientation. -Prosopoagnosia (Πρόσωπον-αγνωσία): The man in the mirror. 3. Hippocampus: Neurons transitioning from healthy (Blue-NeuN marker) to dying (Yellow/orange-AT8 marker). Image credit: Danielle Beckman,
California National Primate Research Center, USA 🇺🇸 - Currently at the Institute for Intelligent Biotechnologies, Helmholtz, Munich, Germany 🇩🇪- 4. Memory and the Creation of Art: the Syndrome, as in de Kooning, of “Creating in the Midst of Dementia”. 5. Memory: Barbra Streisand.
Memory: Sally Fletcher, Harp.

https://www.science.org/content/article/major-highway-human-nervous-system-gets-complete-road-map

Major highway of the human nervous system gets a complete road map First comprehensive map of the vagus nerve may point to more precise stimulation therapies

San Diego, California (USA) 🇺🇸 2010.
1-2-3. L❤️: Sunset Cliffs and Point Loma.
4. Sunset Cliffs and Point Loma.
5. Society for Neuroscience 40th Annual Meeting, Convention Center. 6. Visiting Professor at University of California San Diego School of Medicine (Neuroscience).

Vanderbilt University Medical Center - Nashville, Tennessee 🇺🇸

Monroe Carell Jr. Children’s Hospital at Vanderbilt’s heart-lung support program has once again earned the Platinum Center of Excellence in Life Support award from the Extracorporeal Life Support… | Vanderbilt University Medical Center Monroe Carell Jr. Children’s Hospital at Vanderbilt’s heart-lung support program has once again earned the Platinum Center of Excellence in Life Support award from the Extracorporeal Life Support Organization. This places Monroe Carell’s program among the top 10% in the world. Vanderbilt Healt...

Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections Activated CD8 T cells transiently produce IL-21, creating highly proliferative killers that help control chronic viral infection.