29/09/2020
Alzheimer's has long been known to have genetic links which can be used to predict the inherent susceptibility of an individual to the disease, it doesn’t do much when it comes to what can be done to prevent disease progression. Sleep on the other hand is something we can control and that is something which has been shown to reduce the risks associated with the disease significantly. In fact, recent studies suggest that not just the quantity of sleep but its quality also plays a very important role in delaying the onset of the disease.
Cognitive decline responsible for Alzheimer's is caused by the formation of beta amyloid plaques which accumulate in the brain. This toxic protein destroys memory pathways and other brain functions affecting over 40 million people worldwide.
Now, as one might be aware, sleep is broadly classified into two types: REM (Rapid Eye Movement) sleep and NREM (Non-REM) sleep. NREM sleep is the one in which very less energy is taken up by the body even when compared to REM sleep and in fact one of the stages of NREM sleep is associated with the repair and regeneration of tissues along with aiding the cerebrospinal fluid in flushing out toxic waste.
Researchers at University of California, through the process of polysomnography, which involves recording brain waves, heart rate, breathing and oxygen level in blood, tracked NREM sleep and sleep efficiency which is the amount of time one actually spends sleeping as compared to the time one lies sleepless in bed.
Measuring the build-up of the protein using PET scans, they discovered, in this multi-year study, that quality sleep, with a higher proportion of NREM sleep and higher sleep efficiency, washes away these beta amyloid plaques in early life thus reducing the onset of the disease later. It was interesting to note that these factors remained robust even in the face of differences such as s*x and age.
This gives us a hopeful message as it provides us control over the situation by illustrating that the quality of our sleep today predicts what is going to happen to us years later. This is just one of the many ways in which sleep’s importance once again comes forth.