Chasingresidency

18/08/2026

✅ Correct Answer: A. Chronic Myeloid Leukemia (CML)

🧠 Why?

The classic clues are:

🩸 TLC 85,000/mm³

🧬 Marked neutrophilia with left shift — myelocytes + metamyelocytes

🟣 Basophilia ⭐

🟠 Eosinophilia

🫳 Massive splenomegaly

🔬 Bone marrow → granulocytic hyperplasia

➡️ CML is the most likely diagnosis.

🔑 NEET-PG Exam Pearl

CML = BCR-ABL1 fusion gene → t(9;22) Philadelphia chromosome ⭐

Basophilia + marked leukocytosis + left shift + splenomegaly = CML

❌ PV: predominant erythrocytosis
❌ Primary myelofibrosis: massive splenomegaly + leukoerythroblastosis + teardrop cells
❌ CLL: predominant lymphocytosis

17/08/2026

✅ Correct Answer: A. Behçet Disease

🧠 Why?

The combination is classic:

👄 Recurrent oral ulcers

🔻 Ge***al ulcers

👁️ Uveitis

🔴 Erythema nodosum

💉 Positive pathergy test ⭐

➡️ Oral ulcers + ge***al ulcers + uveitis + positive pathergy = Behçet disease.

🔑 Exam Pearl

Pathergy test positive → Think Behçet disease.

❌ Reiter/reactive arthritis: urethritis + conjunctivitis + arthritis
❌ SLE: malar rash, photosensitivity, anti-dsDNA
❌ Crohn disease: oral ulcers can occur, but ge***al ulcers + uveitis + positive pathergy strongly favor Behçet.

13/08/2026

✅ Correct Answer: A. Primary Biliary Cholangitis (PBC)

🧠 Why?

The key clues are:

🟡 Progressive jaundice + pruritus

👁️ Dry eyes + 👄 dry mouth → Sjögren association

👁️ Xanthelasma

🧪 Cholestatic picture (↑ ALP expected)

⭐ Anti-mitochondrial antibody (AMA) is the classic antibody

Exam pearl:
Middle-aged woman + pruritus + ↑ALP + AMA+ = PBC

24/07/2026

✅ Correct Answer: B. Primary hyperparathyroidism

Why?

Hypercalcemia

↓ Serum phosphate

↑ PTH

Renal stones

Bone pain/osteopenia

Exam Pearl:
“Stones, bones, abdominal groans & psychic moans” + ↑Ca + ↑PTH = Primary hyperparathyroidism.

11/07/2026

✅ Correct Answer: A. Extrahepatic obstructive jaundice

Why?

Direct hyperbilirubinemia

Markedly elevated ALP

Dark urine + pale stools + pruritus

Dilated intrahepatic & common bile ducts on ultrasound

Exam Pearl:
Pruritus + pale stools + high ALP + dilated bile ducts = Obstructive (cholestatic) jaundice.

11/07/2026

✅ Correct Answer: A. Diabetic nephropathy

Why?

Long-standing diabetes

Nephrotic-range proteinuria (>3.5 g/day)

Hypoalbuminemia + edema

Hyperlipidemia

Diabetic retinopathy strongly supports diabetic nephropathy.

Exam Pearl:
Diabetic retinopathy + nephrotic-range proteinuria = Think diabetic nephropathy.

07/07/2026

✅ Correct Answer: A. Community-acquired pneumonia (Lobar pneumonia due to Streptococcus pneumoniae)

Why?

Rusty sputum

Gram-positive diplococci

Sputum culture: Streptococcus pneumoniae

Lobar consolidation on CXR

Neutrophilic leukocytosis

Exam Pearl:
Rusty sputum + Gram-positive diplococci + lobar consolidation = Pneumococcal (lobar) pneumonia.

07/07/2026

✅ Correct Answer: A. Acute poststreptococcal glomerulonephritis (APSGN)

Why?

Recent sore throat (streptococcal infection)

Raised A*O titer

Hematuria + RBC casts

Periorbital edema & hypertension

Mild ↑ creatinine

Exam Pearl:
Hematuria + RBC casts + ↑ A*O after sore throat = APSGN.

07/07/2026

✅ Correct Answer: B. Chronic kidney disease (CKD)

Why?

Diabetes + hypertension (major CKD causes)

↑ Creatinine & ↑ urea

Small kidneys on USG → Chronic disease

Proteinuria + hypoalbuminemia + edema support CKD.

Exam Pearl:
Small kidneys = CKD (except diabetic nephropathy, amyloidosis & polycystic kidney disease may have normal/enlarged kidneys early).

07/07/2026