Csir-Cdri Research Scholars

Ground-breaking study reveals dynamics of DNA replication ‘licensing’

A new study from scientists at the UNC School of Medicine has illuminated an important process that occurs during cell division and is a likely source of DNA damage under some circumstances, including cancer.

consequences of differential origin licensing dynamics in distinct chromatin environments Abstract. Eukaryotic chromosomes contain regions of varying accessibility, yet DNA replication factors must access all regions. The first replication step is lo

https://www.nature.com/articles/d41586-021-01359-3

Mix-and-match COVID vaccines trigger potent immune response Preliminary results from a trial of more than 600 people are the first to show the benefits of combining different vaccines.

DNA Damage to Breast Cells from chemicals in some cosmetics, sunscreens

Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor–Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice Environmental Health Perspectives is an Open Access journal published by the National Institute of Environmental Health Sciences.

A new way to target some rapidly dividing cancer cells, leaving healthy cells unharmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer TRIM37 overexpression promotes centrosome dysfunction that drives genomic instability in breast cancer cell lines containing the recurrent 17q23 amplicon, revealing a vulnerability that can be targeted to eliminate cancer cells.

Viruses that linger in gut could trigger type 1 diabetes

Higher abundance of enterovirus A species in the gut of children with islet autoimmunity Article

The Lypla1 gene impacts obesity in a s*x-specific manner

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits We studied s*x differences in over 50 cardio-metabolic traits in a panel of 100 diverse in**ed strains of mice. The results clearly showed that the ef…

New pill can deliver insulin through the stomach

An ingestible self-orienting system for oral delivery of macromolecules Oral delivery is the simplest and least invasive way to deliver many pharmaceuticals, but many drugs and medications, including insulin, cannot survive passage through the stomach or the gastrointestinal tract. Abramson et al. developed an ingestible delivery vehicle that could self-reorient from an...

Scholars of CDRI are organising a symposium to honor the 2018 Nobel Laureates. We will have lectures by our fellow students. Please attend so that we can make this an early event.