Chromatin Dynamics Laboratory

Excited to share our latest work published in Nature Communications!

We identify TCF19 as a key regulator of hepatocyte adaptation to lipotoxic stress, integrating:
• Fatty acid elongation to reduce lipid toxicity
• Unfolded Protein Response (UPR) to maintain ER homeostasis

Loss of TCF19 exacerbates ER stress and hepatic dysfunction, while its activity protects against palmitate-induced lipotoxicity.

Conceptual advance: A unified transcriptional node linking lipid remodeling with proteostasis in metabolic liver disease.

A huge congratulations to Atanu for driving this work, and to the entire team and collaborators for their effort and dedication. Special thanks to our PI, Prof. Chandrima Das, for her constant guidance and support throughout this study.
Link to the article: https://www.nature.com/articles/s41467-026-72138-9

🌟 Proud Moment for the Lab!
Congratulations to Professor Chandrima Das on being elected Fellow of the Indian National Science Academy (INSA) at the 2025 Annual General Meeting.
A remarkable recognition of her contributions to science and scholarship.

Warmest congratulations from all of us at the lab.

We are happy to share our most recent study, "Protocol for 3D tumor spheroid generation, immunostaining, and imaging through comparative approaches," which was published in STAR PROTOCOLS. In this study, we established lab-grown methods for generating, harvesting, staining, and analyzing multicellular tumor spheroids generated from different cell lines. Here, we also compared and contrasted different approaches to stain and analyse MCTS depending on the experimental needs.
Many congratulations to Atanu, Sandhik, Bipasa, Indrakshi, and Wasim for successfully steering the project towards completion. Also, many thanks to our PI, Chandrima Das, for her guidance and support.
Link to the online article: https://star-protocols.cell.com/protocols/4546

🌟 Heartiest Congratulations to Prof. Chandrima Das on being elected as a Fellow of the Indian National Science Academy (INSA)! 🌟

Her pioneering contributions in unraveling the connections between the epigenome, cancer, matrix remodeling, and immune signaling have been truly inspiring. We, her students, are proud to celebrate this prestigious recognition and fortunate to learn under her guidance. 🙌

We are happy to share our most recent study, "The Hypoxia-Induced Chromatin Reader ZMYND8 Drives HIF-Dependent Metabolic Rewiring in Breast Cancer," which was published in JBC. In this study, we examined how the epigenetic factor ZMYND8 contributes to the metabolome rewiring of breast cancer. Our finding suggests that epigenetic factors in cancer cells can modulate the tumor microenvironment by modulating the metabolic status of cancer cells.
Many congratulations to Sandhik and Atanu for successfully steering the project towards completion. Congratulations to Indrakshi and Wasim for their contribution to this work.
Link to the online article: https://www.jbc.org/article/S0021-9258(25)02532-3/fulltext

We are happy to announce our latest publication of Dr. Audesh Bhat, Ms. Sonali Bhan, Ms. Aindrila Kabiraj, Dr. Raj K. Pandita, Dr. Keneth S. Ramos, Mr. Sandhik Nandi, Ms. Shreya Sopori, Dr. Parthas S. Sarkar, Mr. Arti Dhar, Ms. Shruti Pandita, Dr. Rakesh Kumar, Dr. Chandrima Das, Dr. John A. Tainer, and Dr. Tej K. Pandita entitled “𝐀 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐯𝐞 𝐜𝐡𝐫𝐨𝐦𝐚𝐭𝐢𝐧 𝐚𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 𝐧𝐞𝐱𝐮𝐬 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐭𝐫𝐚𝐧𝐬𝐜𝐫𝐢𝐩𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐃𝐍𝐀 𝐝𝐚𝐦𝐚𝐠𝐞 𝐫𝐞𝐩𝐚𝐢𝐫” published in the along with another article from our lab ' https://doi.org/10.1016/j.jbc.2025.108271 ' in the same issue (Volume 301, Issue 3) of the journal.
The article considers connecting chromatin organization to functional outcomes impacting transcription, DNA repair, and genomic integrity as an emerging grand challenge for predictive molecular cell biology.

Direct access link:
https://doi.org/10.1016/j.jbc.2025.108300
We are grateful to everyone for their respective contributions to the study's objectives.

We are happy to announce our latest publication of Ms. Sinjini Dhang and Mr. Atanu Mondal entitled “Metformin inhibits the histone methyltransferase CARM1 and attenuates H3 histone methylation during gluconeogenesis,” published in the .
The article depicts how the well-known drug metformin inhibits the epigenetic regulator CARM1, leading to a reduction in histone methylation. This process subsequently suppresses gluconeogenic genes, resulting in decreased glucose production in the liver.
We are delighted to share the cover art that has been selected for the publication in the Journal has been created by Atanu Mondal.
Direct access link:
https://doi.org/10.1016/j.jbc.2025.108271

We are grateful to Dr. Siddhartha Roy and Dr. Chandrima Das for their important contributions to the study's objectives.

We are happy to announce our latest publication of Mr. Atanu Mondal ,Mr. Sandhik Nandi, and Dr. Vipin singh, Mr. Arnab Chakraborty, Ms. Indrakshi Banerjee, Dr. Sabyasachi Sen, entitled “TCF7l2 Regulates Fatty Acid Chain Elongase HACD3 during Lipid-Induced Stress” published in the journal .
We are delighted to share the cover art that has been selected for the publication in the Journal

Direct acess link:

https://doi.org/10.1021/acs.biochem.4c00491

We are grateful to Dr. Shrikanth S Gadad, Dr.Siddhartha Roy, Dr. Siddhesh S Kamat,and Dr. Chandrima Das and for their important contributions towards the study's objectives.

Happy times are here again..
We are happy to share that our 7th graduate student of CDL, Mr. Vipin Singh has completed his journey and successfully defended his thesis. All the best for his future endeavors...
Congratulations once again to him...

Happy times are here again..
We are happy to share that our 6th graduate student of CDL, Ms. Swagata Adhikari has completed her journey and successfully defended her thesis. All the best for her future endeavors...
Congratulations once again to her...

Congratulations to Bipasa and Sandhik for their achievements for the best performer award in Post M.Sc. course work in the academic year 2023-2024 (August - July) and 2022 (January-December) respectively.