Regulatory Biology Lab

A Press release of Our Recent Work.
Congratulations Once Again Team!!


https://www.telegraphindia.com/india/covid-calcutta-scientists-offer-clue-to-severe-infections/cid/1825796

New Research Article From Lab,
Published online on August 06, 2021



"Quorum Sensing by Gelsolin Regulates Programmed Cell Death 4 Expression and a Density-Dependent Phenotype in Macrophages"

Congrats!





https://www.jimmunol.org/content/early/2021/08/06/jimmunol.2001392

Another Research Article From Lab,
Published online on December 14, 2020

"Transcriptome-wide analysis reveals spatial correlation between N6-methyladenosine and binding sites of microRNAs and RNA-binding proteins"
Congrats!

Transcriptome-wide analysis reveals spatial correlation between N6-methyladenosine and binding sites of microRNAs and RNA-binding proteins N6-methyladenosine (m6A), the most prevalent epitranscriptomic modification in eukaryotes, is enriched in 3′-untranslated regions (3′UTRs) of mRNAs. A…

New Research Article From Lab,
Published online on December 6, 2020




"RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA"

Congrats!



jbc.org/content/early/2020/12/06/jbc.RA120.014894.long

New Research Article From Lab,
Published online on July 16, 2020



"Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation"

Congrats!

Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation The E3 ubiquitin ligase TRIM21 plays a crucial role as a negative regulator of innate immune responses. Recent evidence has also indicated the involvement of TRIM21 in the genotoxic stress response and suppressing tumorigenesis. Our previous work has demonstrated a new function of TRIM21 in inhibiti...

New Paper from Lab in Collaboration with Dept. of Chemical Sciences, IISER K

"A cyclometalated trinuclear Ir(iii)/Pt(ii) complex as a luminescent probe for histidine-rich proteins"

Equally contributed by Ankita (DCS) and Ravi (DBS).

https://pubs.rsc.org/en/content/articlelanding/2020/dt/c9dt04720d #!divAbstract

Congrats to Team!!

A cyclometalated trinuclear Ir(iii)/Pt(ii) complex as a luminescent probe for histidine-rich proteins - Dalton Transactions (RSC Publishing) Organometallic complexes have important application in the field of protein staining, with potential for use in proteomic analysis. The rational synthesis of a trinuclear luminescent organometallic complex with two platinum(ii) centres appended to the cyclometalated ligand of the iridium(iii) centre...

Poster Presentations from Lab during FIMB...



Well done everyone!!

Senior Most Member of the Lab, Reshma Kumari Sharma will give an oral presentation at FIMB 2020 on February 29.

Title of her talk is "Paracrine Signalling by Gelsolin Regulates Programmed Cell Death 4 Expression and a Density-dependent Phenotype in Macrophages".

Congratulations and Best Wishes for Reshma!!

https://www.cell.com/iscience/fulltext/S2589-0042(19)30138-5
New Article from Lab
Accepted in iScience
Congratulations to all authors...

Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 in Response to DNA Damage Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modelling with experimental validation to elucidate the translation regulatory network that controls p53 expression post DNA dama...

Monalisa Mondal will be presenting her work at "Protein Synthesis and Translational Control"
EMBO CONFERENCE
EMBL Heidelberg, Germany
Title of her talk is "Dual Regulation of Translation of Programmed Cell Death
4 mRNA by the RNA-binding protein ANXA2"

EMBO Conference - Protein Synthesis and Translational Control - 6 - 9 September 2017 In addition to translation of messenger RNA, the conference will feature advances in the field of non-coding RNAs, both small (miRNA) and large (lncRNA), that influence the translation process and its machinery.

New Look of Regulatory Biology Lab at Research Complex, IISER-K

Deepika Ahuja will be presenting at CSH Asia.
http://psraylab.org/nin-hao-china/

Nǐn hǎo, China. In the coming 14th - 18th November, Deepika will be spending her time at Suzhou Dushu Lake Conference Centre of Cold Spring Harbour Asia, learning about the recent advances in the field of RNA biology, attending talks and poster sessions given by various research scholars from across the world, and…