KIMS Pharmacology

Postgraduate pharmacology... Releasing shortly.. comprehensive book for MD pharmacoligists

Vomitting or emesis is a complex physiologic process involving Relaxation of fundic stomach, LES and esophagus. Contraction of pylorus, pyloric end of stomach, and Rhythmic contraction of diaphragm and abdominal muscles. It can be stimulated by multiple factors like psychological, chemical, neuro-hormonal factors. Chemoreceptor trigger zone (CTZ), Dopamine receptor, 5HT3 receptor and opioid receptor play key role in the pathophysiology of Emesis. For a detailed discussion CLICK HERE.

Emetics and Antiemetics Vomitting or emesis is a complex physiologic process involving Relaxation of fundic stomach, LES and esophagus. Contraction of pylorus, pyloric end of stomach, and Rhythmic contraction of diaphragm…

Study objectives: Synthesis of Testosterone Testosterone Preparations and their uses Anabolic steroids Antiandrogens Pharmacotherapy of erectile dysfuntion. Lecture note: CLICK HERE

ANDROGENS AND ANTIANDROGENS Study objectives: Synthesis of Testosterone Testosterone Preparations and their uses Anabolic steroids Antiandrogens Pharmacotherapy of erectile dysfuntion. Lecture note: CLICK HERE

Learning Objectives: Synthesis and Regulation T3 vs T4 Mechanism of Action Possible Sites of interference by drugs Thyroid Inhibitors (Antithyroid drugs, Role of Iodides, Role of I131) For lecture note on thyroid hormone and antithyroid drugs click HERE.

Thyroid Hormone Learning Objectives: Synthesis and Regulation T3 vs T4 Mechanism of Action Possible Sites of interference by drugs Thyroid Inhibitors (Antithyroid drugs, Role of Iodides, Role of I131) For lecture …

This is d diagram of how the powdered sumatriptan acts via d novel delivery system..

Friends - today i m going to share something about a new dosage form of a drug alongwith a unique deliver system...
Intranasal Sumatriptan Powder for the treatment of migraine with or without aura in adult patients. It is not indicated for the prevention of migraine attacks.

The product (formerly called AVP-825) consists of 22 mg of sumatriptan powder delivered by using the novel Xsail breath-activated delivery device.

What does breath-activated mean?

The system is activated by a user's breath. The user exhales into the device, automatically closing the soft palate and sealing off the nasal cavity. Through a sealing nosepiece placed into the nostril, the exhaled breath carries medication from the device directly into one side of the nose.

As the medication is delivered, the air flows around to the opposite side of the nasal cavity and exits through the other nostril. Closure of the soft palate helps prevent swallowing and reduce gastrointestinal absorption.

The system allows the medication to be deposited deep into the nose, an area rich with blood vessels. By delivering the medication here, it provides targeted and efficient delivery with the potential for fast, consistent relief, while also limiting the amount of medicine that goes down the back of the throat.

Read the gist of that approval data here:

The FDA approval was based on data from phase 2 and phase 3 trials, safety data from more than 300 patients, and reference data from the extensive clinical use of sumatriptan over the past 20 years.

Read more abt 'Onsetra Xsail' here: https://www.onzetra.com/

Shared by- Dr. Subham Das

ONZETRA™ Xsail™ (sumatriptan nasal powder) There are several medicines for migraines. The most widely prescribed medicine is sumatriptan, which has been used safely and effectively for over 20 years.

Department of Pharmacology wishes everyone a very happy and prosperous New year

CME organised by our dept....

Representing KIMS as coordinator of adverse drug reaction monitoring center under pharmacovigilance programme of India at IPC Gaziabad is a memorable moment for me. I have got good response from the team of IPC. We require all ur support to make our institute being one to report maximum drug reaction cases of good quality.

The U.S. Food and Drug Administration approved Technivie (ombitasvir, paritaprevir and ritonavir) for use in combination with ribavirin for the treatment of hepatitis C virus (HCV) genotype 4 infections in patients without scarring and poor liver function (cirrhosis).
Technivie in combination with ribavirin is the first drug that has demonstrated safety and efficacy to treat genotype 4 HCV infections without the need for co-administration of interferon.